Editor: Fernando A. Oliveira

Series Title: Recent Advances in Alzheimer Research

Cellular Mechanisms in Alzheimer’s Disease

Volume 2

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)
ISBN: 978-1-68108-716-0 (Print)
ISBN: 978-1-68108-715-3 (Online)
Year of Publication: 2018
DOI: 10.2174/97816810871531180201

Introduction

Alzheimer’s Disease (AD) is the product of the slow and progressive degenerative alteration that develops in the adult brain and can remain asymptomatic for a considerable time before cognitive deficits becomes evident. The main challenge for researchers is to identify markers of this degenerative process, and, in this sense, data has been generated through experiments bringing to light new mechanisms and hypothesis to explain its pathophysiology.

This book is a review of recent studies in AD molecular biology. Chapters explain various facets of AD, which include animal models, morphological changes, membrane composition, amyloidogenic peptides, intracellular transport systems, and the role of oxidative stress and calcium deregulation.

Readers will understand the molecular mechanisms behind AD and therefore broaden their perspective on this neurodegenerative disease and its progression.

Preface

Alzheimer's disease (AD) is the most common cause of dementia worldwide, several groups are involved in studying the predisposition and disease development sought to understand and treat all its consequences.

AD is the product of the slow and progressive degenerative alteration that develops in the adult brain and can remain asymptomatic for a considerable time before the cognitive deficit becomes evident. The main challenge is to identify markers of this degenerative process, in this sense, data have been generated in the field bringing new mechanisms and hypothesis to explain its pathophysiology. This book intends to review the most recent studies in AD and get new perspectives to explain some aspects of this neurodegenerative disease.

The focus of this book is to discuss the cellular mechanisms in AD including well known theories and new perspectives in the main neuronal signaling pathophysiology (β-amyloid and phosphorylate tau). Current concepts on AD will be presented, bringing the more actual information about the cellular mechanisms and new views to explain the disease progress.

Fernando A. Oliveira
Center for Mathematics, Computing and Cognition
Federal University of ABC – UFABC, São Paulo
Brazil
&
Department of Neuroscience
Carleton University, Ottawa
Canada

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