Editors: Ajay Kumar, Avinash Kumar

The Gut-Brain Nexus: The Link Between Gut Microbiota and Neurodegenerative Diseases

eBook: US $99 Special Offer (PDF + Printed Copy): US $179
Printed Copy: US $129
Library License: US $396
ISBN: 979-8-89881-622-3 (Print)
ISBN: 979-8-89881-621-6 (Online)
Year of Publication: 2026
DOI: 10.2174/97988988162161260101

Introduction

Emerging evidence has established the gut microbiota as a key regulator of human health, influencing not only metabolism and immunity but also brain function through the complex gut-brain axis. Growing research suggests that disturbances in this bidirectional communication network may contribute to the onset and progression of several neurodegenerative disorders.

The Gut-Brain Nexus: The Link Between Gut Microbiota and Neurodegenerative Diseases provides a comprehensive overview of the emerging relationship between the gut microbiota and neurological health, highlighting its significance in the development and management of neurodegenerative disorders. Bringing together current scientific evidence and clinical perspectives, the book examines how the gut-brain axis influences brain function and explores the mechanisms through which alterations in the gut microbiome may contribute to disease onset and progression. It is intended as a valuable reference for researchers, healthcare professionals and students interested in neuroscience, microbiology and translational medicine.

The chapters examine the role of the gut microbiota in neurological disorders, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, while also discussing irritable bowel syndrome in the context of the gut-brain axis. The book further explores microbiota-based therapeutic strategies, including probiotics, prebiotics and synbiotics, alongside dietary and lifestyle interventions, commercially available products and current challenges in microbiome modulation. Together, these topics provide readers with a balanced understanding of the therapeutic potential and future directions of gut microbiota research in neurodegenerative diseases.


Target Readership :

Researchers, healthcare professionals and general readers.

Foreword

- Pp. i
Rikeshwer Prasad Dewangan
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Preface

- Pp. ii
Ajay Kumar, Avinash Kumar
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List of Contributors

- Pp. iii-iv (2)

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Gut-Brain Axis: Exploring the Complicated Relationship Between the Gut and the Brain

- Pp. 1-26 (26)
Astik Manju Ashesh, Pranay Wal, Dileep Kumar, Priyanka Tiwari, Avinash Kumar, Ajay Kumar*

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Unravelling the Role of Microbiota in Brain Disorders

- Pp. 27-60 (34)
Rati Kailash Prasad Tripathi*

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The Gut-Brain Connection in Amyotrophic Lateral Sclerosis (ALS) and Its Consequences

- Pp. 61-98 (38)
Sanjana Gupta, Mohamed Nihal P., Astik Manju Ashesh, Mohd Qasid Lari, Sandeep Kumar Singh, Ajay Kumar*

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The Link Between Alzheimer's Disease and Gut Microbiome: A Growing Relationship

- Pp. 99-122 (24)
Prajapati Manisha Anil, Sandesh Kumar Pattanaik, Ashok Kumar Gupta*

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Deciphering the Connection Between Gut Microbiota and Parkinson’s Disease

- Pp. 123-140 (18)
Anmol Kumar, Anjali Gond, Noopur Verma, Ajay Kumar Gupta*

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The Gut Microbiota’s Impact on the Emergence and Development of Neurodegenerative Diseases

- Pp. 141-161 (21)
Mohd Qasid Lari, Astik Manju Ashesh, Avinash Kumar, Dileep Kumar, Ajay Kumar*

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The Gut-Brain Axis in Irritable Bowel Syndrome

- Pp. 162-189 (28)
Manisha Kawadkar*, Deepika Devnani, Avinash Kumar, Dimak Chand Sahu, Arvind Kumar Singh Chandel

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Therapeutic Strategies for Neurodegenerative Diseases via Gut Microbiota Modification

- Pp. 190-208 (19)
Chitrali Talele, Chintan Aundhia, Dipali Talele*, Manisha Lalan, A. K. Seth, Mamta Kumari

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Exploring the Role of Probiotics, Prebiotics, and Symbiotics in The Management of Neurodegenerative Diseases

- Pp. 209-244 (36)
Chintan Aundhia*, Ghanshyam Parmar, Chitrali Talele, Piyush Kumar Sadhu, A. K. Seth

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Diet And Lifestyle Management in Nurturing the Gut-Brain Axis

- Pp. 245-266 (22)
Sandhya Vasanth*, Sindhu Priya E. S., Mohammed Gulzar Ahmed, Sneh Priya, Alima Misiriya

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Gut Microbiome Modulation in Neurodegenerative Diseases: Marketed Products and Challenges

- Pp. 267-284 (18)
Surabhi Shakya, Anchal Srivastava, Alka Yadav, Anurag Verma, Amit Kumar Verma*

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Subject Index

- Pp. 285-290 (6)
Ajay Kumar, Avinash Kumar
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