The Gut-Brain Nexus: The Link Between Gut Microbiota and Neurodegenerative Diseases

Editors: Ajay Kumar, Avinash Kumar

The Gut-Brain Nexus: The Link Between Gut Microbiota and Neurodegenerative Diseases

ISBN: 979-8-89881-622-3
eISBN: 979-8-89881-621-6 (Online)

Introduction

Emerging evidence has established the gut microbiota as a key regulator of human health, influencing not only metabolism and immunity but also brain function through the complex gut-brain axis. Growing research suggests that disturbances in this bidirectional communication network may contribute to the onset and progression of several neurodegenerative disorders.

The Gut-Brain Nexus: The Link Between Gut Microbiota and Neurodegenerative Diseases provides a comprehensive overview of the emerging relationship between the gut microbiota and neurological health, highlighting its significance in the development and management of neurodegenerative disorders. Bringing together current scientific evidence and clinical perspectives, the book examines how the gut-brain axis influences brain function and explores the mechanisms through which alterations in the gut microbiome may contribute to disease onset and progression. It is intended as a valuable reference for researchers, healthcare professionals and students interested in neuroscience, microbiology and translational medicine.

The chapters examine the role of the gut microbiota in neurological disorders, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, while also discussing irritable bowel syndrome in the context of the gut-brain axis. The book further explores microbiota-based therapeutic strategies, including probiotics, prebiotics and synbiotics, alongside dietary and lifestyle interventions, commercially available products and current challenges in microbiome modulation. Together, these topics provide readers with a balanced understanding of the therapeutic potential and future directions of gut microbiota research in neurodegenerative diseases.


Target Readership :

Researchers, healthcare professionals and general readers.

Contributors

Editor(s):
Ajay Kumar
Department of Pharmacology
Sardar Patel College of Pharmacy
Gorakhpur, UP-273013
India


Avinash Kumar
Department of Pharmaceutics
Sardar Patel College of Pharmacy
Gorakhpur, UP-273013
India




Contributor(s):
Ajay Kumar
Department of Pharmacology
Sardar Patel College of Pharmacy
Gorakhpur, UP-273013
India


Ajay Kumar Gupta
School of Pharmaceutical Science (formerly University Institute of Pharmacy)
Chhatrapati Shahu Ji Maharaj University (formerly Kanpur University) campus
Kanpur 208024
India


Amit Kumar Verma
Department of Pharmacy
MJP Rohilkhand University
Bareilly
India


Alima Misiriya
Department of Pharmaceutics
Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to Be University)
Mangalore, 575018, Karnataka
India


Alka Yadav
Rohilkhand College of Pharmacy, BIU
Bareilly
India


Anchal Srivastava
School of Pharmaceutical Sciences
Maharishi University of Information Technology
Lucknow
India


Anmol Kumar
School of Pharmaceutical Science (formerly University Institute of Pharmacy)
Chhatrapati Shahu Ji Maharaj University (formerly Kanpur University) campus
Kanpur 208024
India


Anjali Gond
Department of Biotechnology, Institute of Applied Science and Humanities
GLA University
Mathura, 281406, Uttar Pradesh
India


Anurag Verma
College of Pharmacy, Teerthankar Mahaveer University
Moradabad
India


Arvind Kumar Singh Chandel
School of Engineering
University of Limerick
Limerick, V94 T9PX
Ireland


Astik Manju Ashesh
Department of Pharmacology
Sardar Patel College of Pharmacy
Gorakhpur, UP-273013
India


Ashok Kumar Gupta
School of Pharmacy
Sharda University, Knowledge Park-3
Greater Noida, U.P-201306
India


Avinash Kumar
Department of Pharmaceutics
Sardar Patel College of Pharmacy
Gorakhpur, India-273013
India


A.K. Seth
Department of Pharmacy
Sumandeep Vidyapeeth Deemed to be University
Piparia, Vadodara, Gujarat, 391760
India


Chintan Aundhia
Department of Pharmacy
Sumandeep Vidyapeeth Deemed to be University
Piparia, Vadodara, Gujarat, 391760
India


Chitrali Talele
Department of Pharmacy
Sumandeep Vidyapeeth Deemed to be University
Piparia, Vadodara, Gujarat, 391760
India


Deepika Devnani
School of Pharmacy
GH Raisoni University
Saikheda, Pandhurna (M.P)
India


Dileep Kumar
Department of Pharmaceutical Chemistry
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE)
Manipal, Karnataka, India- 576104
India


Dimak Chand Sahu
School of Pharmacy
GH Raisoni University
Saikheda, Pandhurna (M.P)
India


Dipali Talele
School of Pharmacy
Vishwakarma University, Survey No 2,3,4 Laxmi Nagar, Kondhwa, Budruk
Pune 411048
India


Ghanshyam Parmar
Department of Pharmacy
Sumandeep Vidyapeeth Deemed to be University
Piparia, Vadodara, Gujarat, 391760
India


Mamta Kumari
Department of Pharmacy
Sumandeep Vidyapeeth Deemed to be University
Piparia, Vadodara, Gujarat, 391760
India


Manisha Kawadkar
School of Pharmacy
GH Raisoni University
Saikheda, Pandhurna (M.P)
India


Manisha Lalan
Department of Pharmaceutics
Parul University of Pharmacy & Research, Faculty of Pharmacy, Parul University
Limda, Waghodia-391760, Vadodara, Gujarat
India


Mohamed Nihal P.
Department of Pharmaceutical Chemistry
P.A. College of Pharmacy
Mangalore, Karnataka, 574153
India


Mohammed Gulzar Ahmed
Department of Pharmaceutics
Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to Be University)
Mangalore, 575018, Karnataka
India


Mohd Qasid Lari
Department of Pharmacology
Sardar Patel College of Pharmacy
Gorakhpur, UP-273013
India


Noopur Verma
School of Pharmaceutical Science (formerly University Institute of Pharmacy)
Chhatrapati Shahu Ji Maharaj University (formerly Kanpur University) campus
Kanpur 208024
India


Piyush Kumar Sadhu
Department of Pharmacy
Sumandeep Vidyapeeth Deemed to be University
Piparia, Vadodara, Gujarat, 391760
India


Prajapati Manisha Anil
School of Pharmacy
Sharda University, Knowledge Park-3
Greater Noida, U.P-201306
India


Pranay Wal
Pranveer Singh Institute of Technology
Kanpur, U.P., 209305
India


Priyanka Tiwari
Department of Pharmaceutical Chemistry
KLE College of Pharmacy, Bengaluru, KLE Academy of Higher Education & Research
Karnataka, 560010
India


Rati Kailash Prasad Tripathi
Department of Pharmaceutical Sciences
Sushruta School of Medical and Paramedical Sciences, Assam University (A Central University)
Silchar, Assam
India


Sanjana Gupta
Department of Pharmaceutics
Sardar Patel College of Pharmacy
Gorakhpur, UP-273013
India


Sandeep Kumar Singh
Department of Pharmaceutical Science and Technology
Madan Mohan Malaviya University of Technology
Gorakhpur, Uttar Pradesh
India


Sandhya Vasanth
Department of Pharmaceutics
Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to Be University)
Mangalore, 575018, Karnataka
India


Sandesh Kumar Pattanaik
School of Pharmaceutical Sciences
Siksha 'O' Anusandhan Deemed to be University
Bhubaneswar, Odisha-751003
India


Sindhu Priya E. S.
Department of Pharmacology
Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to Be University)
Mangalore, 575018, Karnataka
India


Sneh Priya
Department of Pharmaceutics
N.G.S.M Institute of Pharmaceutical Science, Nitte (Deemed to Be University)
Mangalore, 575018, Karnataka
India


Surabhi Shakya
Department of Pharmacy
MJP Rohilkhand University
Bareilly
India