Editor: Shamsher Singh

Metals and Neurological Disorders: Exploring Neurotoxicity Mechanisms and Receptor Targets

eBook: US $129 Special Offer (PDF + Printed Copy): US $207
Printed Copy: US $142
Library License: US $516
ISBN: 979-8-89881-526-4 (Print)
ISBN: 979-8-89881-525-7 (Online)
Year of Publication: 2026
DOI: 10.2174/97988988152571260101

Introduction

Metals and Neurological Disorders is a comprehensive exploration of how metal exposure impacts the human nervous system, both physiologically and pathologically. This multidisciplinary volume bridges toxicology, neurobiology, pharmacology, and clinical research to illuminate the complex interactions between metals and neural tissues.

The book begins with fundamental principles of metal homeostasis and progresses through exposure pathways, mechanisms of neurotoxicity, and the pathophysiology of metal-induced neurological disorders. It includes dedicated chapters on metals such as aluminium, lead, and iron, which are commonly implicated in neurodegenerative conditions. Advanced topics cover biomarkers, neuropsychological assessments, and imaging techniques for early diagnosis and targeted intervention.

Emerging tools and strategies such as nanotechnology, nutritional and lifestyle interventions, and translational research are highlighted, providing a bridge from benchside findings to clinical applications. The content is supported with clear diagrams, real-world examples, and up-to-date references, making it both academically rigorous and practically relevant.


Key Features

  • - In-depth coverage of metal homeostasis, neurotoxicity mechanisms, and receptor-level interactions.
  • - Detailed analysis of specific metals (aluminium, lead, iron) and their role in neurological disorders.
  • - Examination of biomarkers, neuropsychological assessments, and advanced imaging for early diagnosis.
  • - Explores translational research, clinical trials, and emerging therapeutic strategies.
  • - Focuses on practical interventions, including nutritional, lifestyle, and nanotechnology-based approaches.
  • - Multidisciplinary perspectives connecting toxicology, neuroscience, medicine, and pharmacology.

Target Readership :

Students, academics, researchers, and professionals in medicine, neuroscience, pharmacology, and toxicology.

Preface

- Pp. i
Shamsher Singh
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List of Contributors

- Pp. ii-iv (3)

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Introduction to the Role of Metals and Neurodegenerative Disorders

- Pp. 1-6 (6)
Dhrita Chatterjee, Romanpreet Kaur, Shamsher Singh*

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Metal Homeostasis in the Human Body

- Pp. 7-27 (21)
Rahul Kumar Sharma, Shilpa Thakur, Karan Sharma, Neelam Sharma*, Tanya Vats, G. D. Gupta, Shamsher Singh

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Metal Toxicity and Human Health: Sources, Exposure Routes, and Preventive Strategies

- Pp. 28-62 (35)
Suraj Sharma, Garima Sharma, Kousik Maparu, Shamsher Singh, Anil Kumar*

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Epidemiological, Preclinical, and Clinical Status: Targeting Metals' Role and Health Status

- Pp. 63-80 (18)
Lovekesh Singh, Komal, G. D Gupta, Sanchi Jain, Shamsher Singh*

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Molecular and Cellular Mechanisms of Metal Exposure-related Neurotoxicity

- Pp. 81-109 (29)
Vaishali Dobhal, Falguni Goel, Romanpreet Kaur, Shamsher Singh*

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Metal Exposure and Attention Deficit Disorders: Molecular Mechanisms and Diagnostic Tools

- Pp. 110-131 (22)
Falguni Goel, Vaishali Dobhal, Vipin Kumar Garg*, Kousik Maparu, Shamsher Singh

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Aluminium Exposure Routes, Absorption, and Excretion Mechanism

- Pp. 132-166 (35)
Sania Grover, R. K. Narang, G. D. Gupta, Kousik Maparu, Shamsher Singh*

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Possible Toxicity of Lead and its Role in the Progression of Neurodegenerative Disorders

- Pp. 167-196 (30)
Navpreet Kaur, Yukti Mittal, Ramandeep Kaur, Shamsher Singh*, Khadga Raj Aran*

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Physiological and Pathological Role of Iron in Neurological Disorders

- Pp. 197-231 (35)
Lav Goyal, R. K. Narang, Dhrita Chatterjee, Kousik Maparu, Shamsher Singh*

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Genetic Variation and Mutation in Neurodegenerative Disorders: Impact of Various Genes

- Pp. 232-259 (28)
Kamal Preet Mehra, Nileshwar Kalia, Shamsher Singh*

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Diagnostic and Therapeutic Approaches to Neurodegenerative Disorders: Biomarkers for Early Detection

- Pp. 260-303 (44)
S. K. Abdul Rahaman*, Sakshi Patel, Sanchi Jain, Prem Shankar Mishra, Rahul Kumar, Naga Rani Kagithala, Ajay Bommareddy, Shamsher Singh

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Metal Dysregulation in Neurodegenerative Disorders: Mechanistic, Preclinical, and Clinical Aspects

- Pp. 304-314 (11)
Lovekesh Singh, G. D. Gupta, Romanpreet Kaur, Shamsher Singh*

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Treatment Options for Metal-associated CNS Toxicity: Clinical Trials and Translational Research

- Pp. 315-349 (35)
Ravina Kumari, Medha Bhalla, Ramandeep Kaur, Ritu Kainth, Kousik Maparu, Shamsher Singh, Ajay Singh Kushwah*

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Metal Imaging and Detection Techniques

- Pp. 350-364 (15)
Sudarshan Kumar, Pavittar Singh, Shamsher Singh, Vivek Asati*

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Role of Nanotechnology as a Treatment Option for Neurodegenerative Disorders

- Pp. 365-379 (15)
Rajesh Kumar, Balwinder Kaur, Subhash Chand, Dhruva Kumar, Lovekesh Singh, Shamsher Singh*

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Lifestyle Management and Exercise as a Tool to Overcome Neurodegenerative Disorders

- Pp. 380-390 (11)
Lovekesh Singh, G. D. Gupta, Dhrita Chatterjee, Shamsher Singh*

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Research Directions and Future Perspectives

- Pp. 391-394 (4)
Kousik Maparu, Dhrita Chatterjee, Romanpreet Kaur, Shamsher Singh*

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Subject Index

- Pp. 395-403 (9)
Shamsher Singh
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