Editor: Gaiqing Wang

Waste Clearance in the Brain

Special Offer (PDF + Printed Copy): US $
Printed Copy: US $65
ISBN: 978-981-5313-09-3 (Print)
ISBN: 978-981-5313-08-6 (Online)
Year of Publication: 2025
DOI: 10.2174/97898153130861240101

Introduction

Waste Clearance in the Brain provides an in-depth exploration of the brain’s essential waste clearance systems, focusing on the glymphatic and cerebrospinal fluid pathways. This book examines the body’s natural defense mechanisms against harmful substances like abnormal proteins and metal deposits linked to neurodegenerative diseases such as Alzheimer’s. With clear explanations, it covers how foreign pathogens and harmful proteins are managed by cerebrospinal fluid, brain vasculature, and the meningeal lymphatic systems. It also discusses cutting-edge research on therapeutic approaches targeting the blood-brain barrier and brain cell regulation.

Key Features:

  • - Comprehensive overview of brain waste clearance pathways and systems
  • - Examination of abnormal protein and metal deposition impacts on brain health
  • - Insights into potential therapies for neurodegenerative diseases
  • - Discussion on the brain’s vascular and immune system roles in waste clearance


Readership

This book is ideal for neuroscientists, neurologists, medical researchers, graduate students, healthcare professionals, and readers interested in neurobiology.

Preface

- Pp. i
Gaiqing Wang
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List of Contributors

- Pp. ii

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Acknowledgements

- Pp. iii
Gaiqing Wang
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Introduction

- Pp. iv-v (2)
Gaiqing Wang
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Entrance of Exotic Pathogens into the Brain

- Pp. 1-8 (8)
Gaiqing Wang, Haiyun Chen*, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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Deposition of Abnormal Proteins in the Brain

- Pp. 9-28 (20)
Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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Harmful Effects of Metal Deposits in the Brain

- Pp. 29-43 (15)
Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen, Shaoping Wu
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Response to Foreign Pathogens in the Brain

- Pp. 44-47 (4)
Gaiqing Wang, Haiyun Chen*, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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Reaction to Abnormal Protein Precipitation in the Brain

- Pp. 48-62 (15)
Gaiqing Wang, Haiyun Chen*, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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Reaction to Abnormal Metal Accumulation in the Brain

- Pp. 63-66 (4)
Gaiqing Wang, Haiyun Chen, Juan Yang, Jing Wang*, Bo Yan, Minglei Chen
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The Function of Neurovascular Unit in Clearance System

- Pp. 67-79 (13)
Gaiqing Wang, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan*, Minglei Chen
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Phagocytosis and Scavenger Receptors in the Brain

- Pp. 80-89 (10)
Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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The Role of Cerebrospinal Fluid in the Clearance System

- Pp. 90-93 (4)
Gaiqing Wang*, Haiyun Chen, Juan Yan, Jing Wang, Bo Yan, Minglei Chen
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The Role of Brain Vasculature and the Perivascular Space

- Pp. 94-97 (4)
Gaiqing Wang, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen*
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The Role of the Glymphatic System

- Pp. 98-106 (9)
Gaiqing Wang, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen*
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The Role of Meningeal Lymphatic Systems

- Pp. 107-112 (6)
Gaiqing Wang, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen*
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The Target Therapeutic Approach for the BBB

- Pp. 113-120 (8)
Gaiqing Wang, Haiyun Chen, Juan Yang*, Jing Wang, Bo Yan, Minglei Chen
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The Regulatory Mechanism Targeting Microglia

- Pp. 121-133 (13)
Gaiqing Wang, Haiyun Chen, Juan Yang*, Jing Wang, Bo Yan, Minglei Chen
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The Regulatory Mechanism for Astrocyte Polarization

- Pp. 134-150 (17)
Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen, Chuntian Liang
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The Regulatory Mechanism for Scavenging Pathways

- Pp. 151-154 (4)
Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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The Regulatory Mechanism for Glymphatic System

- Pp. 155-181 (27)
Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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Effect Factors of Meningeal Lymphatics (MLVs)

- Pp. 182-188 (7)
Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan, Minglei Chen
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References

- Pp. 189-194 (6)
Gaiqing Wang
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List of Abbreviations

- Pp. 195-200 (6)
Gaiqing Wang
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Subject Index

- Pp. 201-206 (6)
Gaiqing Wang
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