Editor: Fernando A. Oliveira

Series Title: Recent Advances in Alzheimer Research

Cellular Mechanisms in Alzheimer’s Disease

Volume 2

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)
ISBN: 978-1-68108-716-0 (Print)
ISBN: 978-1-68108-715-3 (Online)
Year of Publication: 2018
DOI: 10.2174/97816810871531180201

Introduction

Alzheimer’s Disease (AD) is the product of the slow and progressive degenerative alteration that develops in the adult brain and can remain asymptomatic for a considerable time before cognitive deficits becomes evident. The main challenge for researchers is to identify markers of this degenerative process, and, in this sense, data has been generated through experiments bringing to light new mechanisms and hypothesis to explain its pathophysiology.

This book is a review of recent studies in AD molecular biology. Chapters explain various facets of AD, which include animal models, morphological changes, membrane composition, amyloidogenic peptides, intracellular transport systems, and the role of oxidative stress and calcium deregulation.

Readers will understand the molecular mechanisms behind AD and therefore broaden their perspective on this neurodegenerative disease and its progression.

Foreword

- Pp. i-ii (2)
Matthew Holahan
Download Free

Preface

- Pp. iii
Fernando A. Oliveira
Download Free

List of Contributors

- Pp. iv
Fernando A. Oliveira
Download Free

Differences and Implications of Animal Models for the Study of Alzheimerʼs Disease

- Pp. 1-40 (40)
Marcela Bermudez Echeverry, Sonia Guerrero Prieto, Joao Carlos dos Santos Silva, Maria Camila Almeida, Daniel Carneiro Carrettiero
View Abstract

Micro and Macro Morphologic Changes in Alzheimer’s Disease

- Pp. 41-74 (34)
Daniel Moreira-Silva, Samanta Rodrigues, Tatiana L. Ferreira
View Abstract

Alterations of Membrane Composition in Alzheimer´s Disease

- Pp. 75-103 (29)
Manoel Arcisio-Miranda, Rolf Matias Paninka, Luisa Ribeiro-Silva
View Abstract

Amyloidogenic Peptide Structure, Aggregation, And Membrane Interaction

- Pp. 104-139 (36)
Manoel Arcisio-Miranda, Laíz da Costa Silva-Gonçalves
View Abstract

Intracellular Transport System in AD

- Pp. 140-171 (32)
Merari F.R. Ferrari
View Abstract

Alzheimer's Disease and Oxidative Stress

- Pp. 172-201 (30)
Andrea R. Vasconcelos, Paula F. Kinoshita, Cristoforo Scavone, Elisa M. Kawamoto
View Abstract

Calcium Deregulation in Alzheimer’s Disease

- Pp. 202-215 (14)
Vitor S. Alves, Fernanda L. Ribeiro, Daniela R. de Oliveira, Fernando A. Oliveira
View Abstract

Subject Index

- Pp. 215-223 (9)
Fernando A. Oliveira
Download Free

RELATED BOOKS

.Frontiers in Clinical Drug Research - CNS and Neurological Disorders.
.Animal Models for Neurological Disorders.
.Frontiers in Clinical Drug Research – Dementia.
.Frontiers in Clinical Drug Research - CNS and Neurological Disorders.
.Recent Advances in the Treatment of Neurodegenerative Disorders.
.Alzheimer
.Advances in Alzheimer Research.
.Cellular and Molecular Biology of Autism Spectrum Disorders.