Author: Mahbuba Rahman

Series Title: Frontiers in Cancer Immunology

Systems Biology in Cancer Immunotherapy

Volume 2

eBook: US $59 Special Offer (PDF + Printed Copy): US $136
Printed Copy: US $107
Library License: US $236
ISSN: 2405-9102 (Print)
ISSN: 2405-9110 (Online)
ISBN: 978-1-68108-308-7 (Print)
ISBN: 978-1-68108-307-0 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810830701160201


Over the past decades, systems biology approaches have been applied in different areas of life science research including oncology. Researchers now understand the hallmarks of cancer cells such as abnormal cell growth, inflammation, dysregulated metabolic pathways and drug resistance properties at a molecular level. Systems biology approaches have enabled researchers to investigate cancer immunology by identifying cancer related biomarkers on immune cells, and to study the effect of different therapies in tissue cultures and mouse models.

Systems Biology in Cancer Immunotherapy explains the scope of systems biology in understanding the immune response to neoplasms. The book introduces readers to the concepts crucial to cancer immunology before delving into the applied systems biology topics such as the metabolic pathways in cancer cells, the biomolecular roles of signal transduction molecules and immunotherapy. A brief conclusion at the end also provides some information from a clinical and commercial perspective on cancer immunotherapy.

This volume is intended as an introductory reference for life science and medical students, researchers and academics interested in the application of systems biology to the immune system in cancer patients.


I am honoured to be able to contribute to this exciting eBook about Systems Biology in Cancer Immunotherapy. The eBook has excellent credentials for describing important knowledge and approaches for the understanding of cancer cell metabolism and immunotherapy.

Dr. Mahbuba Rahman is one of my former PhD students, and she is among the top students in our laboratory in Kyushu Institute of Technology. She has long been involved in cancer research based on molecular biology as well as 13C-metabolic flux analysis. She has published many articles in this area.

In summary, I am delighted to see such expertly produced and well referenced eBook which will contribute to molecular biology, biochemical science, and medical science.

Kazuyuki Shimizu
Institute of Advanced Biosciences
Keio University
Tsuruoka, Yamagata