Author: Mahbuba Rahman

Series Title: Frontiers in Cancer Immunology

Systems Biology in Cancer Immunotherapy

Volume 2

eBook: US $59 Special Offer (PDF + Printed Copy): US $136
Printed Copy: US $107
Library License: US $236
ISSN: 2405-9102 (Print)
ISSN: 2405-9110 (Online)
ISBN: 978-1-68108-308-7 (Print)
ISBN: 978-1-68108-307-0 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810830701160201


Over the past decades, systems biology approaches have been applied in different areas of life science research including oncology. Researchers now understand the hallmarks of cancer cells such as abnormal cell growth, inflammation, dysregulated metabolic pathways and drug resistance properties at a molecular level. Systems biology approaches have enabled researchers to investigate cancer immunology by identifying cancer related biomarkers on immune cells, and to study the effect of different therapies in tissue cultures and mouse models.

Systems Biology in Cancer Immunotherapy explains the scope of systems biology in understanding the immune response to neoplasms. The book introduces readers to the concepts crucial to cancer immunology before delving into the applied systems biology topics such as the metabolic pathways in cancer cells, the biomolecular roles of signal transduction molecules and immunotherapy. A brief conclusion at the end also provides some information from a clinical and commercial perspective on cancer immunotherapy.

This volume is intended as an introductory reference for life science and medical students, researchers and academics interested in the application of systems biology to the immune system in cancer patients.


- Pp. i
Kazuyuki Shimizu
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- Pp. ii-iii (2)
Mahbuba Rahman
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Immune System in Cancer

- Pp. 3-41 (39)
Mahbuba Rahman
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Cancer Metabolism: A Perspective on the Involvement of the Immune System and Metabolic Pathways in Cancer Development

- Pp. 42-68 (27)
Mahbuba Rahman
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Signal Transduction Molecules and Pathways in Cancer: Implication of the Immune System in Modulating Cancer Development and Progression

- Pp. 69-85 (17)
Mahbuba Rahman
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Cancer Immunotherapy

- Pp. 86-121 (36)
Mahbuba Rahman
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Systems Biology Approach in Cancer Immunotherapy

- Pp. 122-148 (27)
Mahbuba Rahman
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- Pp. 149-154 (6)
Mahbuba Rahman
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Subject Index

- Pp. 155-156 (2)
Mahbuba Rahman
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