Editor: Ashok Kumar Pandurangan

Promising Cancer Therapeutic Drug Targets: Recent Advancements

eBook: US $79 Special Offer (PDF + Printed Copy): US $127
Printed Copy: US $87
Library License: US $316
ISBN: 978-981-5238-58-7 (Print)
ISBN: 978-981-5238-57-0 (Online)
Year of Publication: 2025
DOI: 10.2174/97898153139561210101

Introduction

Promising Cancer Therapeutic Drug Targets: Recent Advancements offers a comprehensive overview of novel and emerging strategies in cancer therapy. The book explores cutting-edge approaches such as exosomal delivery systems, CRISPR/Cas9 gene editing, and immunotoxins, alongside targeting mechanisms like cancer stem cells, apoptosis pathways, and key signaling processes. A strong emphasis is placed on the therapeutic potential of natural compounds in disrupting cancer progression and enhancing treatment response. Chapters are organized around molecular targets, therapeutic pathways, and bioactive agents to provide a clear, thematic structure.

Key Features:

  • - In-depth exploration of CRISPR/Cas9, exosomes, and stem cell-targeted therapy.
  • - Focus on natural compounds in cancer treatment.
  • - Insights into key signaling pathways (Hippo, Hedgehog, STAT3)
  • - Discussion on apoptosis and drug resistance mechanisms.


Readership:

Ideal for students, researchers, and professionals in oncology, pharmacology, and biomedical sciences, this book serves as both an educational resource and a reference for innovative cancer treatments.

Preface

- Pp. i
Ashok Kumar Pandurangan
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List of Contributors

- Pp. ii-iv (3)

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Exosomal Delivery of CRISPR/CAS9 Assembly: Approach towards Cancer Therapeutics

- Pp. 1-26 (26)
Kaumudi Pande, PP Mubthasima, Rajalakshmi Prakash, Anbarasu Kannan*

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Cancer Stem Cells and Their Role in Chemo-Resistance

- Pp. 27-40 (14)
Vaishali Ji, Chandra Kishore*, Krishna Prakash

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Importance of Natural Compounds Targeting the Mitophagic Process in Breast Cancer Treatment

- Pp. 41-65 (25)
Prathibha Sivaprakasam, Karthikeyan Chandrabose, Sureshkumar Anandasadagopan, Hariprasth Lakshmanan, Ashok Kumar Pandurangan*

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Bioactive Natural Compounds as Inhibitors of Signal Transducer and Activator of Transcription 3: Prospects in Anti-Cancer Therapeutics

- Pp. 66-93 (28)
Praveen Deepak*

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Targeting Cancer Stemness by Exosomes as a Therapeutic Approach against Ovarian Cancer

- Pp. 94-112 (19)
Kaumudi Pande, Anbarasu Kannan*

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Sphingosine Kinase as a Target to Treat Gastrointestinal Cancers

- Pp. 113-132 (20)
Mit Joshi, Bhoomika M. Patel*

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Hippo Signaling and its Regulation in Liver Cancer

- Pp. 133-155 (23)
Naveen Kumar Perumal, Vasudevan Sekar, Annapoorna Bangalore Ramachandra, Nivya Vijayan, Vani Vijay, Venkat Prashanth, Madan Kumar Perumal*

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Immunotoxin: A New Generation Agent for Cancer Treatment

- Pp. 156-183 (28)
Subha Ranjan Das, Dibyendu Giri, Tamanna Roy, Surya Kanta Dey, Rumi Mahata, Angsuman Das Chaudhuri, Suman Mondal, Sujata Maiti Choudhury*

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Multifactorial Drug - A Revolution in the Treatment of Cancer by Inhibiting Hedgehog Pathway

- Pp. 184-200 (17)
M. Santosh Kumar*, Poornima D. Vijendra, Pratap G. Kenchappa, A. Gowtami

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Promising Natural Agents for Targeting MicroRNAs in Cancer

- Pp. 201-222 (22)
Rumi Mahata, Subhabrata Das, Suman Mondal, Surya Kanta Dey, Anirban Majumder, Sujata Maiti Choudhury*

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Understanding the Mechanism of Targeted Therapy- The Next Generation for Cancer Treatment

- Pp. 223-237 (15)
K. R. Padma*, K. R. Don, P. Josthna

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Cell Death Apoptotic Pathways and Targeted Therapeutic Research in Cancer

- Pp. 238-252 (15)
Jutishna Bora, Richismita Hazra, Sumira Malik*

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Apoptosis Defects in Cancer and its Therapeutic Implications

- Pp. 253-265 (13)
Jutishna Bora, Sayak Banerjee, Indrani Barman, Sarvesh Rustagi, Richa Mishra, Sumira Malik*

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Subject Index

- Pp. 266-271 (6)
Ashok Kumar Pandurangan
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