Editor: Anna Strunecka

Cellular and Molecular Biology of Autism Spectrum Disorders

eBook: US $91 Special Offer (PDF + Printed Copy): US $164
Printed Copy: US $119
Library License: US $364
ISBN: 978-1-60805-396-4 (Print)
ISBN: 978-1-60805-196-0 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080519601100101

Introduction

Over the past several decades the incidence of autism spectrum disorders (ASD) has increased dramatically. The etiology of ASD remains an unsolved puzzle to scientists, physicians, pediatricians, psychiatrists, and pharmacologists. Our E-book will address what is presently known concerning the pathophysiology of ASD from a cellular and molecular perspective. Our explanation is based on the interaction between repetitive systemic immune stimulation with concomitant chronic brain activation of microglia, which leads to overstimulation of glutamate receptors and inflammatory cytokine receptors. Our E-book will explain, for the first time, the effects of immunoexcitotoxicity on the brain development, neurophysiology, and pathology. Our book will not only attempt to explain the finding in ASD, but will offer treatment proposals that address each of these mechanisms. It will also explain how previous, often successful treatment methods, may indeed operate through the immunoexcitotoxic mechanism.

Foreword

- Pp. i
Stephen M. Edelson
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Preface

- Pp. ii- (1)
Anna Strunecka, Russell L. Blaylock
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List of Contributors

- Pp. iii
Anna Strunecka, Russell L. Blaylock, Mark A. Hyman, Ivo Paclt
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Autism Spectrum Disorders: Clinical Aspects

- Pp. 1-16 (16)
Ivo Paclt, Anna Strunecka
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The Cerebellum in Autism Spectrum Disorders

- Pp. 17-31 (15)
Russell L. Blaylock
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Dysregulation of Glutamatergic Neurotransmission in Autism Spectrum Disorders

- Pp. 32-46 (15)
Anna Strunecka
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Immunoexcitotoxicity as a Central Mechanism of Autism Spectrum Disorders

- Pp. 47-72 (26)
Russell L. Blaylock
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Immune Dysfunction in Autism Spectrum Disorders

- Pp. 73-81 (9)
Russell L. Blaylock
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Gastrointestinal Disorders and Autism Spectrum Disorders: A Causal Link or a Secondary Consequence?

- Pp. 82-99 (18)
Anna Strunecka
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Biochemical Changes in ASD

- Pp. 100-120 (21)
Anna Strunecka
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Searching the Role of Mercury in Autism Spectrum Disorders

- Pp. 121-147 (27)
Anna Strunecka, Russell L. Blaylock
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Fluoride and Aluminum: Possible Risk Factors in Etiopathogenesis of Autism Spectrum Disorders

- Pp. 148-161 (14)
Anna Strunecka, Russell L. Blaylock
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The Role of Melatonin in Etiopathogenesis and Therapy of Autism Spectrum Disorders

- Pp. 162-172 (11)
Anna Strunecka, Russell L. Blaylock, Mark A. Hyman, Ivo Paclt
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The Search for Plausible Role of Oxytocin in Etiology and Therapy of Autism Spectrum Disorders

- Pp. 173-185 (13)
Anna Strunecka, Russell L. Blaylock, Mark A. Hyman, Ivo Paclt
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Regulation of Cortisol Levels in Autistic Individuals and their Mothers

- Pp. 186-198 (13)
Anna Strunecka, Russell L. Blaylock, Mark A. Hyman, Ivo Paclt
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Reproductive Hormones and Autism Spectrum Disorders

- Pp. 199-205 (7)
Russell L. Blaylock
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Addendum. Autism: Is It All in the Head?

- Pp. 206-216 (11)
Mark A. Hyman
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Index

- Pp. 217-223 (7)
Anna Strunecka, Russell L. Blaylock, Mark A. Hyman, Ivo Paclt
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