Editor: Anna Strunecka

Cellular and Molecular Biology of Autism Spectrum Disorders

eBook: US $91 Special Offer (PDF + Printed Copy): US $164
Printed Copy: US $119
Library License: US $364
ISBN: 978-1-60805-396-4 (Print)
ISBN: 978-1-60805-196-0 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080519601100101

Introduction

Over the past several decades the incidence of autism spectrum disorders (ASD) has increased dramatically. The etiology of ASD remains an unsolved puzzle to scientists, physicians, pediatricians, psychiatrists, and pharmacologists. Our E-book will address what is presently known concerning the pathophysiology of ASD from a cellular and molecular perspective. Our explanation is based on the interaction between repetitive systemic immune stimulation with concomitant chronic brain activation of microglia, which leads to overstimulation of glutamate receptors and inflammatory cytokine receptors. Our E-book will explain, for the first time, the effects of immunoexcitotoxicity on the brain development, neurophysiology, and pathology. Our book will not only attempt to explain the finding in ASD, but will offer treatment proposals that address each of these mechanisms. It will also explain how previous, often successful treatment methods, may indeed operate through the immunoexcitotoxic mechanism.

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