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Targeted Oncometabolism: New Frontiers in Cancer Therapy – Part 1

Editors: Mithun Bhowmick, Pratibha Bhowmick, Prashant Tiwari, Steward Mudenda

Targeted Oncometabolism: New Frontiers in Cancer Therapy – Part 1

ISBN: 979-8-89881-880-7
eISBN: 979-8-89881-879-1 (Online)

Introduction

Cancer cells rewire their metabolism to fuel tumor growth, spread, and drug resistance. This book traces the field from early observations of altered glucose use to current translational practice, covering glycolysis, glutamine, lipid, and one-carbon pathways. It examines how the tumor microenvironment shapes metabolic adaptation and reviews therapeutic strategies that target these dependencies. Contributors from academia and clinical practice bridge molecular biology, immunology, and pharmacology, offering both mechanistic insight and a view toward precision-guided oncology.


Key Features

  • - Covers core metabolic pathways and their therapeutic vulnerabilities.
  • - Explores hypoxia, stromal and immune influences on metabolic heterogeneity.
  • - Reviews inhibitors, synthetic lethality, and nanotechnology delivery.
  • - Discusses single-cell metabolomics, CRISPR, and AI modeling.
  • - Links laboratory findings to patient care via case studies and trial data.

Target Readership :

Researchers, clinicians, postgraduate students, and pharmaceutical science professionals.

Foreword

Cancer remains a major obstacle in modern medicine, requiring innovative strategies beyond traditional treatments. Our understanding of cancer has shifted from a focus on genetics to a broader perspective that recognizes metabolic reprogramming as a critical feature of tumor development. As precision oncology advances, targeting cancer metabolism has become a promising area for new therapeutic approaches.

I am delighted to present Targeted Oncometabolism: New Frontiers in Cancer Therapy, a comprehensive volume edited by Dr. Mithun Bhowmick, Dr. Pratibha Bhowmick, Dr. Prashant Tiwari and Dr. Steward Mudenda. This book is a vital resource for researchers, clinicians, and academics exploring the complex metabolic changes that drive cancer growth and resistance. Through carefully selected chapters, leading experts explore key aspects of cancer metabolism, including mitochondrial dynamics, lipid metabolism, and metabolic interactions within the tumor microenvironment.

A standout feature of this book is its emphasis on translating metabolic discoveries into practical therapeutic strategies. It covers innovative approaches like metabolic inhibitors, immunometabolism, and synthetic lethality, showcasing the evolving field of cancer treatment and the potential for more precise, effective therapies.

The editors have skillfully brought together diverse perspectives, connecting basic research with clinical applications. Their commitment to advancing oncometabolism is clear in the thorough discussions throughout the book. As cancer treatment progresses, incorporating metabolic vulnerabilities into precision medicine will be crucial for improving patient outcomes.

I am confident that Targeted Oncometabolism: New Frontiers in Cancer Therapy will be an invaluable resource for professionals in cancer research and treatment. It deepens our understanding of cancer metabolism and encourages further innovation in the development of effective therapies. I applaud the editors and contributors for their outstanding work and for delivering such a timely and significant contribution to the scientific community.

Deepak S. Khobragade
Department of Pharmacognosy,
Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education
(Deemed to be University, Wardha, Maharashtra, India