In Silico and In vitro Approaches to Screen the Anti-TB Activity of Benzothiazole Analogs

Editors: Mahesh Bhat, S.L. Belagali

In Silico and In vitro Approaches to Screen the Anti-TB Activity of Benzothiazole Analogs

ISBN: 978-981-14-9461-1
eISBN: 978-981-14-9463-5 (Online)


This monograph presents information about the history and evolution of tuberculosis treatment, and the potential of the benzothiazole moiety for anti-tuberculosis (anti-TB) activity. The book introduces the reader to basic information about benzothiazole as a drug candidate before delving into the anti-tubercular properties of derivative compounds in subsequent chapters. The contributors explain quantitative structural-activity relationships of benzothiazole with anti-TB activity along with the importance of in-silico (computer aided) techniques in the drug design process. This is followed by a chapter which details Mycobacterium tuberculosis biology, strains as well as symptoms of tuberculosis infections. The book then explains in-vitro and in-vivo methods used to evaluate drug efficacy against tuberculosis along with the synthesis and anti-TB activity of the benzothiazole derivatives (benzothiazole diamide, benzothiazole guanidinyl derivatives and benzothiazole conjugated pyrazole derivatives).

This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.


Tuberculosis is a serious infectious disease, which is caused by the Mycobacterium tuberculosis, generally it affects the lungs. Tuberculosis is spread from one person to another through microscopic droplets released into the air, it can happen through coughs, speaks, sneezes, spits, laughs from the active tuberculosis patient. According to the recent survey on tuberculosis by world Health Organization, in 2018, 10 million people fell ill with TB, and 1.5 million died from the disease. These numbers are alarming the need for more efforts to fight against the tuberculosis.

The book entitled “In-Silico and In-Vitro Approaches to Screen the Anti-tuberculosis Activity of Benzothiazole Analogs” comprises of six chapters, with extensive literature documentation on the benzothiazole analogs and corresponding structure activity relations, further authors enumerated the in-vitro and in-silico methodology for the screening the benzothiazole molecules to the anti-TB regime. Further various chapters explained the synthesis of the different types of the benzothiazole scaffold moiety and their tuberculosis activities with neat descriptions of the methodology. Additionally, each chapter includes the synthetic schemes, with mechanism for the benzothiazole derivatives.

I am happy to recommend this book to students and researchers of the Universities and research centers as a reference book. This book is written in the way that it is student friendly with the help of the diagrams, tables, reaction schemes and mechanisms. This book helps to get the glimpse on tuberculosis diseases and the wide information to carry out further research on the benzothiazole. I sincerely believe that, this book has been prepared with scientific skills and experimental details and will serve as a useful document for the researchers.

B. Shivarama Holla
Professor of Chemistry
SDM College (autonomous)
Ujire, Dakshina Kannada
574240, India


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