In Silico and In vitro Approaches to Screen the Anti-TB Activity of Benzothiazole Analogs

Editors: Mahesh Bhat, S.L. Belagali

In Silico and In vitro Approaches to Screen the Anti-TB Activity of Benzothiazole Analogs

ISBN: 978-981-14-9461-1
eISBN: 978-981-14-9463-5 (Online)

Introduction

This monograph presents information about the history and evolution of tuberculosis treatment, and the potential of the benzothiazole moiety for anti-tuberculosis (anti-TB) activity. The book introduces the reader to basic information about benzothiazole as a drug candidate before delving into the anti-tubercular properties of derivative compounds in subsequent chapters. The contributors explain quantitative structural-activity relationships of benzothiazole with anti-TB activity along with the importance of in-silico (computer aided) techniques in the drug design process. This is followed by a chapter which details Mycobacterium tuberculosis biology, strains as well as symptoms of tuberculosis infections. The book then explains in-vitro and in-vivo methods used to evaluate drug efficacy against tuberculosis along with the synthesis and anti-TB activity of the benzothiazole derivatives (benzothiazole diamide, benzothiazole guanidinyl derivatives and benzothiazole conjugated pyrazole derivatives).

This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.

Contributors

Editor(s):
Mahesh Bhat


S.L. Belagali




Contributor(s):
Belagali S.L.
Environmental Chemistry Laboratory
DOS in Environmental Science, University of Mysore
Mysore-06, Karnataka
India


Mahesh Bhat
Department of Chemistry
JSS College for Women, Saraswathipuram
Mysore-09, Karnataka
India


Mamatha S.V.
Environmental Chemistry Laboratory
in Environmental Science, University of Mysore
Mysore-06, Karnataka
India


Manohara B.
Department of Chemistry
Vivekananda College
Puttur-574 203, Karnataka
India


Sagar B.K.
Department of Chemistry
MDRPU Science College
Varakodu, Mysore-570 010, Karnataka
India


Vijaya Sekhar E.
Department of Chemistry
JSS College for women, Saraswathipuram
Mysore-09, Karnataka
India




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