Editors: Mahesh Bhat, S.L. Belagali

In Silico and In vitro Approaches to Screen the Anti-TB Activity of Benzothiazole Analogs

eBook: US $49 Special Offer (PDF + Printed Copy): US $83
Printed Copy: US $59
Library License: US $196
ISBN: 978-981-14-9461-1 (Print)
ISBN: 978-981-14-9463-5 (Online)
Year of Publication: 2021
DOI: 10.2174/97898114946351210101

Introduction

This monograph presents information about the history and evolution of tuberculosis treatment, and the potential of the benzothiazole moiety for anti-tuberculosis (anti-TB) activity. The book introduces the reader to basic information about benzothiazole as a drug candidate before delving into the anti-tubercular properties of derivative compounds in subsequent chapters. The contributors explain quantitative structural-activity relationships of benzothiazole with anti-TB activity along with the importance of in-silico (computer aided) techniques in the drug design process. This is followed by a chapter which details Mycobacterium tuberculosis biology, strains as well as symptoms of tuberculosis infections. The book then explains in-vitro and in-vivo methods used to evaluate drug efficacy against tuberculosis along with the synthesis and anti-TB activity of the benzothiazole derivatives (benzothiazole diamide, benzothiazole guanidinyl derivatives and benzothiazole conjugated pyrazole derivatives).

This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.

Foreword

- Pp. i
B. Shivarama Holla
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Preface

- Pp. ii-iii (2)
Mahesh Bhat
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List of Contributors

- Pp. iv
Mahesh Bhat and S.L. Belagali
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Introduction to Benzothiazole as a Drug Moiety

- Pp. 1-18 (18)
Mahesh Bhat, S.L. Belagali, B. Manohara and B.K. Sagar

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Structural Activity Relationship and In-Silico Methods in Drug Design

- Pp. 19-43 (25)
Mahesh Bhat, S.L. Belagali and E.V. Sekhar

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Mycobacterium Tuberculosis and In-Vitro Methods for Screening Anti-TB Drugs

- Pp. 44-65 (22)
Mahesh Bhat, S.L. Belagali, B. Manohara and S.V. Mamatha

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Synthesis and Anti-TB Activity Screening of Benzothiazole Amide Derivatives

- Pp. 66-76 (11)
Mahesh Bhat and S.L. Belagali

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Synthesis and Anti-TB Activity Studies of Benzothiazole Guanidinyl Derivatives

- Pp. 77-89 (13)
Mahesh Bhat and S.L. Belagali

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Synthesis and Anti-TB Activity Screening of Pyrazole Conjugated Benzothiazole Analogs

- Pp. 90-107 (18)
Mahesh Bhat and S.L. Belagali

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Subject Index

- Pp. 108-116 (9)
Mahesh Bhat and S.L. Belagali
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