Editor: Tommaso Claudio Mineo

Malignant Pleural Mesothelioma: Present Status and Future Directions

eBook: US $99 Special Offer (PDF + Printed Copy): US $228
Printed Copy: US $179
Library License: US $396
ISBN: 978-1-68108-194-6 (Print)
ISBN: 978-1-68108-193-9 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810819461160101

Introduction

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually increasing among the global human population. Mesothelioma prognosis in patients is usually poor and their life expectancy is significantly reduced. This edited monograph presents holistic information about malignant mesothelioma in one volume. Readers will gain knowledge of the etiology, immunopathology of this disease and will understand the rationale for new treatment methods. The initial section of the book gives the historical context of mesothelioma in medicine. Subsequent sections illustrate mesothelioma epidemiology with respect to the problem of asbestos diffusion in different areas of the world such as Europe, The Americas, East Asia, Australia and Africa. This is followed by chapters detailing current information about asbestos and non-asbestos molecular biology and etiopathogenesis, as well as intriguing insights from human genetics and translational medicine. Other sections in this volume focus on clinical information; mesothelioma diagnosis and staging are thoroughly described with a focus on serum biomarkers and pleural liquid cytology. Additional sections provide information on treatment modalities, with one section dedicated to surgical procedures.

Malignant Pleural Mesothelioma: Present Status and Future Directions is a comprehensive informational resource with well organized sections, aided by protocol charts, tables and figures. The book is essential for both medical oncology students and specialists who want to augment or update their knowledge about this neoplasm.

About the Editor

- Pp. i
Tommaso Claudio Mineo
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Foreword

- Pp. iii
Shaf Keshavjee
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Preface

- Pp. v-vi (6)
Tommaso Claudio Mineo
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Contributors

- Pp. vii-x (4)
Tommaso Claudio Mineo
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Holistic Care of People with Malignant Pleural Mesothelioma: A Thirty Year Perspective

- Pp. 3-11 (9)
Tom Treasure

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History of Malignant Pleural Mesothelioma

- Pp. 13-24 (12)
Peter Bartrip

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Natural History of Malignant Pleural Mesothelioma

- Pp. 25-31 (7)
Anish Thomas and Raffit Hassan

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Epidemiology of Malignant Pleural Mesothelioma in Europe

- Pp. 33-52 (20)
Andrew Darnton, Clare Gilham and Julian Peto

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Epidemiology of Malignant Pleural Mesothelioma in the Americas

- Pp. 53-71 (19)
Bruce W. Case

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Epidemiology of Malignant Pleural Mesothelioma in Japan and South Korea

- Pp. 73-81 (9)
Takashi Nakano, Kozo Kuribayashi, Soon-Hee Jung and Hyoung-Ryoul Kim

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Epidemiology of Malignant Pleural Mesothelioma in Australia

- Pp. 83-93 (11)
Nicholas de Klerk, Fraser Brims, Alison Reid, Peter Franklin, Nola Olsen, Tim Threlfall, Keith Shilkin and A. William Musk

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Epidemiology of Malignant Pleural Mesothelioma in Africa

- Pp. 95-113 (19)
Gill Nelson and Jim teWaterNaude
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Asbestos and Malignant Pleural Mesothelioma

- Pp. 115-128 (14)
Matthew J. Soeberg and Nico van Zandwijk

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Environmental Non-Asbestos Related Causes of Malignant Pleural Mesothelioma

- Pp. 129-144 (16)
Francine Baumann and Jean-Paul Ambrosi

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Virus Oncogenesis of Malignant Pleural Mesothelioma

- Pp. 145-154 (10)
Giovanni Gaudino, Fang Qi, Haining Yang and Michele Carbone

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Genetics of Malignant Pleural Mesothelioma

- Pp. 155-168 (14)
Dean A. Fennell, Annabel J. Sharkey and Sara Busacca

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Biomolecular Pathways and Malignant Pleural Mesothelioma

- Pp. 169-192 (24)
Marie-Claude Jaurand and Didier Jean

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Somatic and Germline BAP1 Mutations in Malignant Mesothelioma

- Pp. 193-203 (11)
Andrea Napolitano, Laura Pellegrini, Haining Yang and Michele Carbone

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Anatomic Pathology of Malignant Pleural Mesothelioma

- Pp. 205-212 (8)
Alfredo D’Avino and Alfonso Baldi

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Imaging Evaluation in Malignant Pleural Mesothelioma

- Pp. 213-231 (19)
Beth A. Ripley and Ritu R. Gill

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Present Role of Cytology in Diagnosing Malignant Pleural Mesothelioma

- Pp. 233-246 (14)
Anders Hjerpe and Katalin Dobra

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Serum Biomarkers in Malignant Pleural Mesothelioma

- Pp. 247-256 (10)
Ian M. Dick and Jenette Creaney

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Prognostic Factors in Malignant Pleural Mesothelioma

- Pp. 257-283 (27)
Tommaso Claudio Mineo and Vincenzo Ambrogi

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Pleural Effusion Management in Malignant Pleural Mesothelioma

- Pp. 285-303 (19)
Maree Azzopardi and Gary Y.C. Lee

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Chemotherapy in Malignant Pleural Mesothelioma

- Pp. 305-320 (16)
Wei-Sen Lam and Anna K. Nowak

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Radiation Therapy of Malignant Pleural Mesothelioma

- Pp. 321-334 (14)
Hale Basak Caglar

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Novel Genetic Therapies in Malignant Pleural Mesothelioma

- Pp. 335-346 (12)
Assunta De Rienzo and Raphael Bueno

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Virus Therapies in Malignant Pleural Mesothelioma

- Pp. 347-361 (15)
Manish R. Patel

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Future Prospects in Chemotherapy for Malignant Pleural Mesothelioma

- Pp. 363-386 (24)
Xiang Hua Zhang, Birgitta I Hiddinga and Jan P van Meerbeeck

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Staging Systems and Current Guidelines in Malignant Pleural Mesothelioma

- Pp. 387-398 (12)
Christopher Cao

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Thoracoscopy in Diagnosis and Treatment of Malignant Pleural Mesothelioma

- Pp. 399-411 (13)
Rocco Bilancia, Annabel Sharkey and David A. Waller

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Value of Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma

- Pp. 413-427 (15)
Andrea S. Wolf and Raja H. Flores

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Lung Sparing Surgery for Malignant Pleural Mesothelioma

- Pp. 429-440 (12)
Robert B. Cameron

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Surgical Treatment after Radiotherapy in Malignant Pleural Mesothelioma

- Pp. 441-451 (11)
Laura Donahoe and Marc de Perrot

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Surgical Treatment after Chemotherapy in Malignant Pleural Mesothelioma

- Pp. 453-467 (15)
Isabelle Opitz and Walter Weder

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Results after Intraoperative Therapy in Malignant Pleural Mesothelioma

- Pp. 469-478 (10)
Shamus R. Carr and Joseph S. Friedberg

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Complications after Surgery for Malignant Pleural Mesothelioma

- Pp. 479-490 (12)
Zeynep Bilgi and Hasan F. Batirel

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Clinical Impact of Surgery for Malignant Pleural Mesothelioma

- Pp. 491-514 (24)
Tommaso Claudio Mineo and Vincenzo Ambrogi

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Analysis of Therapies for Malignant Pleural Mesothelioma: Words that Count, Numbers that Speak

- Pp. 515-520 (6)
Francesca Fiorentino and Tom Treasure

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Subject Index

- Pp. 521-528 (8)
Tommaso Claudio Mineo
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