Editors: Ahmad Salehi, Michael Rafii, Cristy Phillips

Series Title: Recent Advances in Alzheimer Research

Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy

Volume 1

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)
ISBN: 978-1-68108-139-7 (Print)
ISBN: 978-1-68108-138-0 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810813801150101

Introduction

Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's disease. Unfortunately, no extant treatments have proven beneficial for cognitive dysfunction for either Down syndrome or Alzheimer’s disease. An incomplete understanding of the common pathogenic mechanisms that link these two disorders has limited researchers’ progress to this end. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a novel attempt to fill this void, by summarizing the work of world-renowned scientists in the field of Alzheimer’s disease and Down syndrome, and thus providing an unprecedented opportunity to attract attention to Down syndrome as a tool for understanding the common molecular mechanisms that underlie Alzheimer’s disease and to develop new therapies for similar neurodegenerative disorders of the brain.

The book covers the fundamental pathophysiology and molecular mechanisms behind the incidence of Alzheimer’s disease in Down syndrome affected individuals as well other key topics such as diagnosis and management, in vivo brain imaging studies, and progressive neurodegeneration of the monoaminergic system. The book concludes with a review of recent clinical trials of drugs designed to mitigate cognitive dysfunction in aging adults with Down syndrome and establishes a scientific warrant for the increased testing of candidate pharmacotherapies.

Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a useful reference clinicians involved in treating Down syndrome patients as well as for neuroscience researchers seeking to understand the influence of a specific case of aneuploidy on Alzhemier’s disease incidence and its progression at the molecular level.

Contributors

Editor(s):
Ahmad Salehi
Department of Psychiatry and Behavioral Sciences
Stanford University School of Medicine and VA Palo Alto Health Care System (WRIISC)
Palo Alto, California
USA


Michael Rafii
Department of Neurosciences
University of California, San Diego
San Diego, California
USA


Cristy Phillips
Department of Physical Therapy
Arkansas State University
Jonesboro, Arkansas
USA




Contributor(s):
Ahmad Salehi
Department of Psychiatry & Behavioral Sciences
Stanford University School of Medicine, VA Palo Alto Health Care System (WRIISC)
Palo Alto
California
USA


Ai-Ling Ling
Sanders-Brown Center on Aging
University of Kentucky
Lexington
Kentucky
USA
/
Department of Pharmacology & Nutritional Sciences
University of Kentucky
Lexington
Kentucky
USA


Amy M. Pooler
Basic and Clinical Neuroscience
King’s College London
London
UK


Ann-Charlotte Granholm
Department of Neurosciences
Medical University of South Carolina
South Carolina
USA


Atoossa Fahimi
VA Palo Alto Health Care System (WRIISC)
Palo Alto, California
USA


Betsy Pohlman
Oakland, California
USA


Biswaroop Chakrabarty
Child Neurology Division, Department of Pediatrics
All India Institute of Medical Sciences,
New Delhi
India


Brian T. Gold
Sanders-Brown Center on Aging
University of Kentucky
Lexington
Kentucky
USA
/
Department of Pharmacology & Nutritional Sciences
University of Kentucky
Lexington
Kentucky
USA


Carmen Martínez-Cué
Department of Physiology and Pharmacology
University of Cantabria
Santander
Spain


Cristy Phillips
Department of Physical Therapy
Arkansas State University
Arkansas
USA


Damien Colas
Department of Biology,
Stanford University
371 Serra Mall, Stanford
California
USA


David Powell
Magnetic Resonance Imaging and Spectroscopy Center
University of Kentucky
Lexington
Kentucky
USA
/
Department of Anatomy and Neurobiology
University of Kentucky
Lexington
Kentucky
USA


Debomoy K. Lahiri
Department of Psychiatry
Indiana University School of Medicine
Indiana
USA


Donna M. Wilcock
Sanders-Brown Center on Aging
University of Kentucky
Lexington
Kentucky
USA
/
Department of Physiology and Department of Neurology
University of Kentucky
Lexington
Kentucky
USA


Elizabeth Head
Sanders-Brown Center on Aging
University of Kentucky
Lexington
Kentucky
USA
/
Department of Pharmacology & Nutritional Sciences
University of Kentucky
Lexington
Kentucky
USA


Fatemah Mojabi
VA Palo Alto Health Care System (WRIISC)
Palo Alto, California
USA


Frances K. Wiseman
Institute of Neurology
University College London
London
UK


Frederick A. Schmitt
Sanders-Brown Center on Aging
University of Kentucky
Lexington
Kentucky
USA
/
Department of Physiology and Department of Neurology
University of Kentucky
Lexington
Kentucky
USA


George T. Capone
Department of Pediatrics, Johns Hopkins University
School of Medicine, Neurodevelopmental Medicine, Kennedy Krieger Institute
Maryland
USA


Kumar Sambamurti
Department of Neurosciences
Medical University of South Carolina
South Carolina
USA


Laura J. Pulford
Institute of Neurology
University College London
London
UK


Meghan O’Neill
Johns Hopkins University SOM, Neurodevelopmental Medicine
Kennedy Krieger Institute
Maryland
USA


Michael S. Rafii
Down Syndrome Research and Treatment Center, UC San Diego Health System
La Jolla, California
USA


Miguel A. Pappolla
Department of Neurology
University of Texas
Medical Branch
Texas
USA


H. Greig Nigel
Drug Design & Development Section
National Institute on Aging
Maryland
USA


Noemí Rueda
Department of Physiology and Pharmacology
University of Cantabria
Santander
Spain


Panneerselvam Chinnakannu
Department of Neurosciences
Medical University of South Carolina
South Carolina
USA


Rachana Dubey
Child Neurology Division, Department of Pediatrics
All India Institute of Medical Sciences
New Delhi
India


Sarah Müller
Basic and Clinical Neuroscience
King’s College London
London
UK


Sheffali Gulati
Child Neurology Division, Department of Pediatrics
All India Institute of Medical Sciences
New Delhi
India


Shoumitro Deb
Department of Medicine, Division of Brain Sciences
Imperial College London
London
UK


Vasudevaraju Padmaraju
Department of Neurosciences
Medical University of South Carolina
South Carolina
USA




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