Editors: Ahmad Salehi, Michael Rafii, Cristy Phillips

Series Title: Recent Advances in Alzheimer Research

Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy

Volume 1

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)
ISBN: 978-1-68108-139-7 (Print)
ISBN: 978-1-68108-138-0 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810813801150101

Introduction

Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's disease. Unfortunately, no extant treatments have proven beneficial for cognitive dysfunction for either Down syndrome or Alzheimer’s disease. An incomplete understanding of the common pathogenic mechanisms that link these two disorders has limited researchers’ progress to this end. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a novel attempt to fill this void, by summarizing the work of world-renowned scientists in the field of Alzheimer’s disease and Down syndrome, and thus providing an unprecedented opportunity to attract attention to Down syndrome as a tool for understanding the common molecular mechanisms that underlie Alzheimer’s disease and to develop new therapies for similar neurodegenerative disorders of the brain.

The book covers the fundamental pathophysiology and molecular mechanisms behind the incidence of Alzheimer’s disease in Down syndrome affected individuals as well other key topics such as diagnosis and management, in vivo brain imaging studies, and progressive neurodegeneration of the monoaminergic system. The book concludes with a review of recent clinical trials of drugs designed to mitigate cognitive dysfunction in aging adults with Down syndrome and establishes a scientific warrant for the increased testing of candidate pharmacotherapies.

Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a useful reference clinicians involved in treating Down syndrome patients as well as for neuroscience researchers seeking to understand the influence of a specific case of aneuploidy on Alzhemier’s disease incidence and its progression at the molecular level.

Preface

- Pp. i-iv (4)
Cristy Phillips, Ahmad Salehi, Michael Rafii
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Acknowledgements

- Pp. v
Cristy Phillips, Ahmad Salehi, Michael Rafii
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List of Contributors

- Pp. vi-vii (2)
Cristy Phillips, Ahmad Salehi, Michael Rafii
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The Management and Treatment of Down Syndrome and Alzheimer’s Disease: Political and Ethical Issues

- Pp. 3-19 (17)
Betsy Pohlman
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Clinical Aspects of Down Syndrome with Alzheimer’s Disease Symptomatology

- Pp. 20-41 (22)
George Capone, Meghan O`Neill
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Diagnosing Alzheimer’s Dementia in People with Down Syndrome

- Pp. 42-68 (27)
Shoumitro Deb
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Managing Problem Behaviors in People with Down Syndrome and Alzheimer`s Disease

- Pp. 69-89 (21)
Shoumitro Deb
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Sleep Abnormalities in Down Syndrome and Alzheimer’s Disease: Cognitive Consequences and New Therapeutic Strategies

- Pp. 90-115 (26)
Damien Colas
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Role of Seizures in the Pathophysiology of Down Syndrome and Alzheimer’s Disease

- Pp. 116-125 (10)
Sheffali Gulati, Biswaroop Chakrabarty, Rachana Dubey
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In Vivo Brain Imaging in Down Syndrome: Functional and Structural Similarities with Alzheimer’s Disease

- Pp. 126-150 (25)
Elizabeth Head, David Powell, Brian T. Gold, Ai-Ling Ling, Donna M. Wilcock, Frederick A. Schmitt
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Neuropathological Phenotype in Alzheimer’s Disease and Down Syndrome: Chemical Nature and Anatomical Localization

- Pp. 151-172 (22)
Laura J. Pulford, Sarah Müller, Frances K. Wiseman, Amy M. Pooler
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The Role of Inflammatory Processes in the Pathophysiology of Down Syndrome and Alzheimer’s Disease

- Pp. 173-188 (16)
Donna M. Wilcock, Elizabeth Head
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Mouse Models of Down Syndrome and Alzheimer’s Disease: Similarities and Differences

- Pp. 189-248 (60)
Noemí Rueda, Carmen Martínez-Cué
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Role of APP in the Pathophysiology of Down Syndrome and Alzheimer’s Disease

- Pp. 249-272 (24)
Kumar Sambamurti, Miguel A. Pappolla, Debomoy K. Lahiri, Nigel H. Greig, Panneerselvam Chinnakannu, Ann-Charlotte Granholm, Vasudevaraju Padmaraju
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Evolution of Monoaminergic System Degeneration in Down Syndrome and Alzheimer’s Disease

- Pp. 273-291 (19)
Cristy Phillips, Atoossa Fahimi, Fatemeh S. Mojabi, Ahmad Salehi
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Overview of Recent Clinical Trials for Cognitive Dysfunction in Alzheimer’s Disease and Down Syndrome

- Pp. 292-300 (9)
Michael S. Rafii
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Concluding Remarks

- Pp. 301-302 (2)
Ahmad Salehi, Michael Rafii, Cristy Phillips
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Subject Index

- Pp. 303-308 (6)
Cristy Phillips, Ahmad Salehi, Michael Rafii
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