Editor: Debomoy K. Lahiri

Advances in Alzheimer Research

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library License: US $356
ISSN: 2589-2797 (Print)
ISSN: 2214-4358 (Online)
ISBN: 978-1-60805-714-6 (Print)
ISBN: 978-1-60805-495-4 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080549541130101

Introduction

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alzheimer Research, provides researchers with an integrated approach to AD academic literature ranging from basic to advanced clinical research. The series highlights the latest information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book series is, therefore, to capture and discuss both, improvements towards the diagnosis and potential treatment of AD by established and novel strategies.

This first volume of the series provides an important mechanism to bring individuals having a variety of scientific interests and expertise under one roof to specifically focus on AD and related dementias. This volume presents articles on beta amyloid protein targets as well as research on secretase enzyme systems among other topics that deal with AD therapy.

Preface

- Pp. i-vi (6)
Debomoy K. Lahiri
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List of Contributors

- Pp. vii-xi (5)
Debomoy K. Lahiri
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How and When Environmental Agents and Dietary Factors Affect the Course of Alzheimer’s Disease: The “LEARn” Model (Latent Early-Life Associated Regulation) May Explain the Triggering of AD

- Pp. 3-27 (25)
Debomoy K. Lahiri, Bryan Maloney, Md Riyaz Basha, Yuan Wen Ge and Nasser H. Zawia

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Therapeutics Targeting Intracellular Amyloid β-Protein in Alzheimer’s Disease: A Novel Effect of Apomorphine

- Pp. 28-46 (19)
Yasumasa Ohyagi

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Protection Mechanisms Against Aβ42 Aggregation

- Pp. 47-64 (18)
Yilin Yan, Christopher Connors and Chunyu Wang

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An Increase in Aβ42 in the Prefrontal Cortex is Associated with a Reversal Learning Impairment in Alzheimer’s Disease Model Tg2576 APPsw Mice

- Pp. 65-80 (16)
Jia-Min Zhuo, Annamalai Prakasam, Melissa E. Murray, Hai-Yan Zhang, Mark G. Baxter, Kumar Sambamurti and Michelle M. Nicolle

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The Regulation of &#946;APP and PrP<sup>c</sup> Processing by &#945;-Secretase

- Pp. 81-104 (24)
Bruno Vincent, Moustapha Cissé, Claire Sunyach, Marie-Victoire Guillot-Sestier and Frédéric Checler

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Regulation and Activation of Metalloproteinase-Mediated APP &#945;-Secretase Cleavage

- Pp. 105-127 (23)
Rolf Postina
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Taking Down the Unindicted Co-Conspirators of Amyloid &#946;-Peptide-Mediated Neuronal Death: Shared Gene Regulation of BACE1 and APP Genes Interacting with CREB, Fe65 and YY1 Transcription Factors

- Pp. 128-146 (19)
Debomoy K. Lahiri, Yuan-Wen Ge, Jack T. Rogers, Kumar Sambamurti, Nigel H. Greig and Bryan Maloney

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The What, Where, and How of &#947;-Secretase Complex Assembly

- Pp. 147-186 (40)
Daniel R. Dries and Gang Yu

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Pro-Inflammatory Cytokines and Anti-Inflammatory Drugs Modulate Glial Expression of Apolipoprotein E Protein

- Pp. 187-204 (18)
Judes Poirier, Rosanne Aleong and Dorothée Domenger

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Lipoprotein Receptors in Alzheimer´s Disease: Beyond Lipoprotein Transport

- Pp. 205-233 (29)
Wladislaw Maier, Sebastian Jaeger and Claus U. Pietrzik

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Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies

- Pp. 234-259 (26)
Alejandra del C. Alonso, Bin Li, Inge Grundke-Iqbal and Khalid Iqbal

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Prevalence of Neuropsychiatric Symptoms in Alzheimer’s Disease and Vascular Dementia

- Pp. 260-280 (21)
Manuel Fernández-Martínez, Jassica Castro, Ana Molano, Juan J. Zarranz, Rosa M. Rodrigo and Rafael Ortega

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Fatty Aspirin: A New Perspective in the Prevention of Dementia of Alzheimer’s Type?

- Pp. 281-318 (38)
Massimo F.L. Pomponi, Massimiliano Pomponi and Giovanni Gambassi

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Index

- Pp. 319-329 (11)
Debomoy K. Lahiri
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