Editor: Vasilios E. Papaioannou

Series Title: Frontiers in Myocardia

Septic Cardiomyopathy: from bench-to-bedside

Volume 1

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2451-8344 (Print)
ISSN: 2451-8352 (Online)
ISBN: 978-1-68108-061-1 (Print)
ISBN: 978-1-68108-060-4 (Online)
Year of Publication: 2015
DOI: 10.2174/97816810806041150101


Frontiers in Myocardia is an eBook series which compiles information about the structure and function of myocardial (the heart muscles) and includes updated reviews on the recent developments in the treatment of associated diseases such as angina, cardiac arrhythmias and myocardial infarction.

Advances in research on clinical sepsis in the last few decades have lead to the use of new concepts and treatment paradigms that have been tested and implemented in the clinical setting of Intensive Care Units around the world. An integrative approach towards understanding the pathophysiology of cardiac dysfunction in septic patients can, therefore, lead to better patient outcomes.

The first volume of this series, Septic Cardiomyopathy: from bench-to-bedside, integrates new and old information about the molecular mechanisms, histopathological and electrophysiological alterations with novel findings for diagnosing treating septic cardiomyopathy. This eBook attempts to bridge the gap between basic and clinical scientists and presents new data on different aspects of cardiac physiology during critical illness in a single volume. Chapters in this volume also cover cardiovascular changes that occur as a consequence of sepsis including metabolic, mitochondrial arrhythmic changes.

This eBook will add significant value to medical students, cardiac physicians and medical scientists engaged in the field of critical care medicine.


Sepsis is a systematic process that involves all cells and at all levels from intracellular genomic expression, subcellular organelle especially mitochondrial function, cell signaling and organ function. It would be amazing if sepsis did not also alter myocardial function. However, unlike simple ischemic heart disease, the mechanisms and expression of septic cardiomyopathy is more complex and often confusing. This new eBook addresses the various aspects of these processes in a single volume. The authors are all leaders in this field and their insights offer a clear pathway toward understanding the field as it is now and where it is going. I recommend this volume to any acute care physician and scientist whose focus is critical illness and whose goal is to improve the care of the critically ill septic patient.

Michael R. Pinsky
Department of Critical Care Medicine
606 Scaife Hall, 3550 Terrace Street, University of Pittsburgh Medical Center,
Pittsburgh, PA 15261,
Tel: (412) 647-7766,
Fax: (412) 647-8060
E-mail: e.pinskymr@upmc.edu


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