Editors: Adilson Beatriz, Dênis Pires de Lima

Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

eBook: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library License: US $196
ISBN: 978-1-60805-903-4 (Print)
ISBN: 978-1-60805-902-7 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080590271140101

Introduction

The World Health Organization (WHO) has reported 14 diseases that are occurring exclusively in tropical areas. Most of these diseases are infectious and mainly affect poor populations. Some of these diseases include malaria, dengue fever, leishmaniasis and Chagas disease. Therefore, an acute need for increasing the arsenal of drugs is required to fight against these neglected diseases for the guaranteed recovery and relief of many patients.

This E-book gathers important scientific research performed by scientists worldwide showing the state of the art of Medicinal Chemistry dedicated to the synthesis of compounds that are potentially bioactive against the causative agents of neglected diseases.

The contents of this book include chapters on recent advances in synthetic organic compounds for the prevention of Chagas disease, recent advances in the discovery of small organic molecules for the prevention and treatment of dengue fever, leishmaniasis, leprosy, therapeutic arsenal and drug discovery for lymphatic filariasis, therapeutic agents for the treatment of malaria, schistosomiasis and synthetic organic compounds as potential antitubercular drugs.

This book is intended for undergraduate and graduate students in institutes, colleges, universities and academies who want to specialize in the field of organic synthesis and medicinal chemistry. This book will also be a valuable resource of information for researchers in this field.

Foreword

Half the disease burden of the developing world – 80% of the world’s population – is due to infectious and parasitic diseases, most of which are preventable and/or treatable. More than 1 billion people is affected by at least one neglected tropical diseases (NTDs), primarily poor populations living in tropical and subtropical climates, with an approximated 534 000 deaths per year. These diseases have a huge impact on labor productivity and costs low-income countries billion of dollars a year, keeping up the vicious circle of poverty. Yet despite these alarming numbers, between 1975 and 1999 only thirteen new drugs were approved that targeted NTDs. Fortunately, over the past decade the tide has began to turn, in both recognizing the lack of new medicines dedicated to the diseases of the most neglected populations and in initiating efforts to redress the problem. In recent years, there has been a remarkable commitment on the part of ministries of health in endemic countries, global health initiatives, funding agencies and philanthropists escalated, as did donations of medicines from pharmaceutical companies and the engagement of the scientific community, having efforts towards the infectious diseases of the developing world. In this scenario, medicinal and synthetic chemists are of upmost importance, for designing, synthetizing and evaluating new drug candidates for parasitic and infectious diseases. This eBook is dedicated to the theme of “Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases” and features contributions from a Brazilian team of synthetic chemists and pharmaceutical researchers that work in the field of synthesis of compounds that are potentially bioactive against the causative agents of NTDs.

Carolina Horta Andrade
LabMol - Laboratory for Molecular Modeling and Drug Design
Faculdade de Farmácia
Universidade Federal de Goiás
Rua 240, Qd. 87
Setor Leste Universitário, 74605-170
Goiânia - GO
Brazil


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