Editors: Adilson Beatriz, Dênis Pires de Lima

Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

eBook: US $49 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $119
Library License: US $196
ISBN: 978-1-60805-903-4 (Print)
ISBN: 978-1-60805-902-7 (Online)
Year of Publication: 2014
DOI: 10.2174/97816080590271140101

Introduction

The World Health Organization (WHO) has reported 14 diseases that are occurring exclusively in tropical areas. Most of these diseases are infectious and mainly affect poor populations. Some of these diseases include malaria, dengue fever, leishmaniasis and Chagas disease. Therefore, an acute need for increasing the arsenal of drugs is required to fight against these neglected diseases for the guaranteed recovery and relief of many patients.

This E-book gathers important scientific research performed by scientists worldwide showing the state of the art of Medicinal Chemistry dedicated to the synthesis of compounds that are potentially bioactive against the causative agents of neglected diseases.

The contents of this book include chapters on recent advances in synthetic organic compounds for the prevention of Chagas disease, recent advances in the discovery of small organic molecules for the prevention and treatment of dengue fever, leishmaniasis, leprosy, therapeutic arsenal and drug discovery for lymphatic filariasis, therapeutic agents for the treatment of malaria, schistosomiasis and synthetic organic compounds as potential antitubercular drugs.

This book is intended for undergraduate and graduate students in institutes, colleges, universities and academies who want to specialize in the field of organic synthesis and medicinal chemistry. This book will also be a valuable resource of information for researchers in this field.

Preface

In the website of WHO, 14 diseases are reported to occur exclusively or specially in tropics. Most of them are infectious diseases affecting mainly poor populations and include leishmaniosis, dengue fever, malaria and Chagas disease. These diseases affect around 1 billion people and, according to WHO, 100% of developing countries are affected by at least five of these diseases. Accordingly, there is an urgent necessity for increasing the arsenal of drugs to combat neglected diseases in order to guarantee relief and well-being to many patients. The situation requires powerful research and improvement of politics to support investigation in this area of knowledge. There is a great volume of scientific work dealing with biology, immunology and genetics of parasites which cause these diseases. Taking in account the present situation, the role of Organic Chemistry in the pharmaceutical industry continues to be one of the main propellers for the discovery of new drugs. Medicinal organic chemists have contributed by seeking new bioactive compounds. Nowadays, there is a considerable global effort to evoke awareness to this problem and overcome the persisting inequality in the focus of drug discovery. Therefore, this eBook gathers important scientific research performed by scientists worldwide showing the state of the art of Organic Medicinal Chemistry dedicated to the synthesis of compounds that are potentially bioactive against the causative agents of neglected diseases. The eBook intends to be a valuable source of information to researchers in the area of Medicinal Chemistry, Organic Synthesis, as well as to undergraduate and graduate students interested in this subject.

The eBook is composed of eight chapters, each of which is dedicated to one type of neglected disease. Essentially, the authors compiled important work concerning the synthesis and biological evaluation, according to their targets, of lead compounds in the process of developing new pharmaceuticals.

Adilson Beatriz
&
Dênis Pires de Lima
Institute of Chemistry
Federal University of Mato Grosso do Sul
Campo Grande – MS
Brazil

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