Editor: Benedict C. Albensi

Transcription Factors CREB and NF-κB: Involvement in Synaptic Plasticity and Memory Formation

eBook: US $34 Special Offer (PDF + Printed Copy): US $136
Printed Copy: US $119
Library License: US $136
ISBN: 978-1-60805-418-3 (Print)
ISBN: 978-1-60805-257-8 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080525781120101

Introduction

The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-κB have been implicated in memory as well. Of these, scientific literature on NF-κB’s theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-κB have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Chemical Abstracts, Scopus, EBSCO.

Contributors

Editor(s):
Benedict C. Albensi
University of Manitoba
Canada




Contributor(s):
Benedict C. Albensi
Division of Neurodegenerative Disorders
St. Boniface General Hospital Research Centre
351 Tache Ave, St. Boniface Research Centre, R4050
Winnipeg
MB, R2H 2A6
R2H 2A6Canada
/
Department of Pharmacology and Therapeutics
University of Manitoba
Winnipeg, MB, A203 Chown Bldg., 753 McDermot Avenue
Winnipeg
MB, R3T 2N2
R2H 2A6Canada


Steven W. Barger
Department of Geriatric
Department of Neurobiology and Developmental Sciences
University of Arkansas for Medical Sciences
Little Rock AR, 72205
USA
/
Geriatric Research Education and Clinical Center
Central Arkansas Veterans Healthcare System
Little Rock AR, 72205
USA


Ángel M. Carrión
División de Neurociencias
Universidad Pablo de Olavide
Carretera de Utrera Km. 1
Sevilla-41013, Spain



Ángela Fontán-Lozano
División de Neurociencias
Universidad Pablo de Olavide
Carretera de Utrera Km. 1
Sevilla-41013, Spain



Mariagrazia Grilli
DiSCAFF, University of Piemonte Orientale “A. Avogadro” & DFB Center
Laboratory of Neuroplasticity and Pain
Novara , 28100
Italy


Sheena A. Josselyn
Program in Neurosciences & Mental Health
Hospital for Sick Children Research Institute
555 University Ave
Toronto
ON, M5G 1X8
Canada
/
Department of Physiology
University of Toronto
1 King's College Circle
Toronto
ON, M5S 1A8
Canada


Xianrong R. Mao
Department of Anesthesiology
Washington University School of Medicine
St. Louis MO, 63110
USA


Vasco Meneghini
Applied Neurotherapeutics Research Group
UCD School of Biomolecular and Biomedical Science
Conway Institute, University College Dublin
Belfield
Dublin 4
Ireland


Keith J. Murphy
School of Electrical and Electronic Engineering
Nanyang Technological University
Block S1, Level B1C, Room 100
Nanyang Link, 639798
Singapore


Gary Odero
Division of Neurodegenerative Disorders
St. Boniface General Hospital Research Centre
351 Tache Ave, St. Boniface Research Centre
Winnipeg MB
R2H 2A6
Canada


Niamh C. O’Sullivan
Applied Neurotherapeutics Research Group
UCD School of Biomolecular and Biomedical Science
Conway Institute, University College Dublin
Belfield
Dublin 4
Ireland


Eva M. Pérez-Villegas
División de Neurociencias
Universidad Pablo de Olavide
Carretera de Utrera Km. 1
Sevilla-41013
Spain


Asim J. Rashid
Program in Neurosciences & Mental Health
Hospital for Sick Children Research Institute
555 University Ave
Toronto ON
M5G 1X8
Canada


Arturo Romano
Laboratorio de Neurobiología de la Memoria
Departamento de Fisiología, Biología Molecular y Celular
Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires,
IFIBYNECONICET
Ciudad Universitaria
Pab. II, 2do Piso (1428)
Buenos Aires
Argentina


Rocío Romero-Granados
División de Neurociencias
Universidad Pablo de Olavide
Carretera de Utrera Km. 1
Sevilla-41013
Spain


Graham K. Sheridan
Applied Neurotherapeutics Research Group
UCD School of Biomolecular and Biomedical Science, Conway Institute
University College Dublin
Belfield
Dublin 4
Ireland


Wanda Snow
Division of Neurodegenerative Disorders
St. Boniface General Hospital Research Centre,
351 Tache Ave
St. Boniface Research Centre
R4050, Winnipeg
MB, R2H 2A6
Canada


Kunjumon Vadakkan
Division of Neurodegenerative Disorders
St. Boniface General Hospital Research Centre,
351 Tache Ave
St. Boniface Research Centre
R4050, Winnipeg
MB, R2H 2A6
Canada




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