Editors: Thomas C. Chen, Marc Chamberlain

Avastin and Malignant Gliomas

Volume 1

Personal Book: US $79 Special Offer (PDF + Printed Copy): US $158
Printed Copy: US $119
Library Book: US $316
ISSN: 2210-5565
ISBN: 978-1-60805-519-7
eISBN: 978-1-60805-132-8 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080513281100101

Introduction

Neuro-oncology is an embryonic field of cancer research with a number of clinical trials in progress. However, the prognosis on neuro-oncologic patients has remained poor. Moreover, several small scale phase I/II trials performed have proved to be inconclusive because of the limited number of patients involved. As a result, many controversies exist in neuro-oncology drug development for which a forum does not exist. This ebook presents a detailed account on the use of avastin in treating cancer patients. A discussion on clinical experiences and the controversial debate among researchers of avastin's role in restricting malignant gliomas is also included giving readers a diverse perspective on the rationale of treating CNS tumors.

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Contributors

Editor(s):
Thomas C. Chen
University of Southern
California
USA


Marc Chamberlain
University of Washington
USA




Contributor(s):
Manish K. Aghi
Department of Neurological Surgery
505 Parnassus Avenue, Rm M779
San Francisco, CA 94143-0112
USA


Dawit Aregawi
University of Michigan Hematology/Oncology
C369 Med Inn Building
1500 E Medical Center SPC 5848
Ann Arbor
MI, 48109-5848
USA


Neyns Bart
UZ Brussel
Laarbeeklaan 101
Brussel, 1090
Belgium


Tracy Batchelor
Stephen E. and Catherine Pappas Center for Neuro-Oncology
Yawkey 9E, Massachusetts General Hospital Cancer Center
55 Fruit Street
Boston
MA, 02114
USA


Mitchel S. Berger
Department of Neurological Surgery
505 Parnassus Avenue
Rm M779
San Francisco
CA, 94143-0112
USA


Jaishri Blakeley
Department of Neurology
The Johns Hopkins Oncology Center
600 North Wolfe Street
Baltimore
MD, 21287
USA


Nicholas Butowski
Department of Neuro-Oncology
Brain Tumor Research Center
University of California, San Francisco 400 Parnassus Avenue A808
San Francisco
California, 94143-0350
USA


Arnab Chakravarti
Ohio State University
Columbus
Ohio
USA


Marc C. Chamberlain
Fred Hutchinson Cancer Center, Seattle Cancer Care Alliance
825 Eastlake Ave E, POB 10923, MS: G4-940
Seattle
WA, 98109-1023
USA


Susan Chang
Department of Neuro-Oncology
Brain Tumor Research Center, University of California
San Francisco 400 Parnassus Avenue, A808
San Francisco
California, 94143-0350
USA


Thomas C. Chen
Departments of Neurosurgery
Keck School of Medicine
University of Southern California
Los Angeles
CA, 90033
USA


Annick Desjardins
Duke University Medical Center DUMC
Box 3624
Durham
NC, 27710
USA


Jörg H. Dietrich
Stephen E. and Catherine Pappas Center for Neuro-Oncology
Yawkey 9E, Massachusetts General Hospital Cancer Center
55 Fruit Street
Boston
MA, 02114
USA


Jan Drappatz
Center for Neuro-Oncology
Dana Farber Cancer Institute
44 Binney Street, SW-430D
Boston
MA, 02115
USA


Elizabeth R. Gerstner
Stephen E. and Catherine Pappas Center for Neuro-Oncology
Yawkey 9E, Massachusetts General Hospital Cancer Center
55 Fruit Street
Boston
MA, 02114
USA


Mark R. Gilbert
M. D. Anderson Cancer Center 1515 Holcombe Blvd.
Unit 431 Houston
Texas, 77030
USA


Rachel Grossman
Department of Neurosurgery
The Johns Hopkins Oncology Center
600 North Wolfe Street
Baltimore
MD, 21287
USA


Helen Gu
Norris Cancer Center
1441 Eastlake Ave.
Los Angeles
CA, 90033
USA


Philip H. Gutin
Department of Neurological Surgery
Weill Medical College of Cornell University
New York
USA


John W. Henson
Neurology
Swedish Neuroscience Institute
Suite 500, 550 17th Avenue
Seattle
WA, 98122
USA


Florence M. Hofman
Departments of Pathology
Keck School of Medicine
University of Southern
California
USA


Fabio M. Iwamoto
National Institute of Neurological Disorders and Stroke, National Institutes of Health
Bethesda
Maryland


L. Kamsheh
Northwestern University, Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center, 710 N. Lake Shore Drive
Abbott Hall, Room 1123
Chicago
IL, 60611
USA


Bart Keogh
Neuroradiology, Swedish Neuroscience Institute
550 17th Avenue, Suite 500
Seattle
WA, 98122
USA


Teri N. Kreisl
Neuro-Oncology Branch – NCI 9030
Old Georgetown Road, Bldg. 82, Rm. 243
Bethesda
MD, 20892
USA


Victor A. Levin
Department of Neuro-Oncology
The University of Texas, M. D. Anderson Cancer Center
Houston
TX, 77030
USA


Minesh Mehta
University of Wisconsin
Madison
WI
USA


T. Mikkelsen
Hermelin Brain Tumor Center, Depts. Neurology & Neurosurgery
E&R3096 Henry Ford Hospital 2799 West Grand Blvd
Detroit
MI, 48202
USA


Y.S. Mohan
Hermelin Brain Tumor Center, Depts. Neurology & Neurosurgery
E&R3096 Henry Ford Hospital 2799 West Grand Blvd
Detroit
MI, 48202
USA


L. Burt Nabors
Neuro oncology Program, University of Alabama at Birmingham
510 20th Street South, FOT 1020
Birmingham
AL, 35294
USA


Andrew D. Norden
Brigham and Women's Hospital , Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School
Boston
MA, 02115
USA


Disha Patel
Ohio State University
Columbus
Ohio
USA


Michael Platten
Department of Neurooncology
University Hospital of Heidelberg
Im Neuenheimer Feld 400, D-69120
Heidelberg
Germany


Whitney B. Pope
David Geffen School of Medicine, Department of Radiology
University of California
Los Angeles
USA


Gazanfar Rahmathulla
Brain Tumor and NeuroOncology Center
Cleveland Clinic, 9500 Euclid Ave
Cleveland
OH, 44195
USA


Jeffrey Raizer
Northwestern University, Feinberg School of Medicine
Robert H. Lurie Comprehensive Cancer Center
710 N. Lake Shore Drive, Abbott Hall, Room 1123
Chicago
IL, 60611
USA


David A. Reardon
Preston Robert Tisch Brain Tumor Center at Duke
Duke University Medical Center, Box 3624
Durham
NC, 27710
USA


Lisa R. Rogers
University Hospitals, Case Western Reserve Medical Center
11100 Euclid Avenue, Hanna House 517
Cleveland
Ohio, 44106
USA


Sith Sathornsumetee
Neuro-Oncology Program, Department of Medicine
Faculty of Medicine
Siriraj Hospital, Mahidol University
Bangkok
Thailand


David Schiff
University of Virginia, Health System
Box 800432
Charlottesville
VA, 22908-0432
USA


Roger Stupp
Department of Neurosurgery
University Hospital (CHUV)
Rue du Bugnon 46 CH-1011
Lausanne
Switzerland


R. Thind
Hermelin Brain Tumor Center, Depts. Neurology & Neurosurgery
E&R3096 Henry Ford Hospital 2799 West Grand Blvd
Detroit
MI , 48202
USA


M.J. Van den Bent
Dept Neuro-Oncology
Daniel den Hoed Cancer Center, Erasmus University Hospital
Rotterdam
The Netherlands


Michael A. Vogelbaum
Brain Tumor and Neuro-Oncology Center, Center for Translational Therapeutics, Department of Neurological Surgery
Cleveland Clinic / Neurological Institute
9500 Euclid Ave.
Cleveland
OH, 44195
USA


James V. Vredenburgh
Department of Medicine
The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center
Durham
NC, 27710
USA


Daphne Wang
Stephen E. and Catherine Pappas Center for Neuro-Oncology, Yawkey 9E, Massachusetts General Hospital Cancer Center
55 Fruit Street
Boston
MA, 02114
USA


Michael Weller
University Hospital Zurich
Switzerland


Patrick Y. Wen
Center for Neuro-Oncology, Dana Farber Cancer Institute
44 Binney Street, SW-430D
Boston
MA, 02115
USA


Antje Wick
Department of Neurooncology
University Hospital of Heidelberg
Im Neuenheimer Feld 400, D-69120
Heidelberg
Germany


Wolfgang Wick
Department of Neurooncology
University Hospital of Heidelberg
Im Neuenheimer Feld 400, D-69120
Heidelberg
Germany


Jing Wu
Dept of Neuro-Oncology
M. D. Anderson Cancer Center
1515 Holcombe Blvd., Unit 431
Houston
Texas, 77030
USA




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