Editor: Claudio Hetz

Protein Misfolding Disorders: A Trip into the ER

eBook: US $59 Special Offer (PDF + Printed Copy): US $136
Printed Copy: US $107
Library License: US $236
ISBN: 978-1-60805-575-3 (Print)
ISBN: 978-1-60805-013-0 (Online)
Year of Publication: 2009
DOI: 10.2174/97816080501301090101

Introduction

Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This Ebook gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context.

Contributors

Editor(s):
Claudio Hetz
Institute of Biomedical Sciences, University of Chile
Chile




Contributor(s):
Claudio Hetz
Institute of Biomedical Sciences University of Chile
Independencia 1027 P.O. BOX 70086
Santiago
Chile


Randal J. Kaufman
University of Michigan Medical Center
Howard Hughes Medical Institute
Ann Arbor
MI , 48109-0650
USA


Amy S Lee
USC/Norris Comprehensive Cancer Center
University of Southern California Keck School of Medicine
Los Angeles
California , 90089
USA


J.D. Atkin
University of Melbourne
Howard Florey Institute
Parkville
Victoria, 3010
Australia


Fumihiko Urano
University of Massachusetts Medical School
Worcester
MA , 01605
USA


Takashi Momoi
Divisions of Development and Differentiation Department of Human Inherited Metabolic Disease
National Institute of Neuroscience
4-1-1 Ogawahigashi-machi
Kodaira
Tokyo , 187-8502
Japan


Hidenori Ichijo
Cell Signaling Graduate School of Pharmaceutical Sciences
The University of Tokyo
7-3-1 Hongo Bunkyo-ku
Bunkyo-ku
Tokyo , 113-0033
Japan


Nibaldo C. Inestrosa
Centro de Envejecimiento y Regeneración (CARE) Facultad de Ciencias Biológicas
Pontificia Universidad Católica de Chile
Santiago
Chile


Othman Ghribi
Department of Pharmacology Physiology and Therapeutics
University of North Dakota School of Medicine
Grand Forks
ND, 58202
USA


Claudio Soto
Protein Misfolding Disorders Laboratory, Dept of Neurology
George and Cynthia Mitchell Center for Neurodegenerative Diseases, University of Texas Medical School at Houston
USA


J. Paul Taylor
Department of Developmental Neurobiology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis
TN , 38120
USA


Danny Galleguillos
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Vicente Valenzuela
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Pamela Valdés
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Alexis Martínez
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Soledad Matus
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Melissa Nassif
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Mauricio Torres
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Gabriela Martínez
FONDAP Center for Molecular Studies of the Cell
University of Chile
Santiago
Chile
/
Faculty of Medicine
Independencia 1027
Santiago
Chile


Sung Hoon Back
Howard Hughes Medical Institute University of Michigan Medical Center
Ann Arbor
MI , 48109-0650
USA


Justin R. Hassler
Howard Hughes Medical Institute University of Michigan Medical Center
Ann Arbor
MI , 48109-0650
USA


Risheng Ye
University of Southern California Keck School of Medicine
Los Angeles
California , 90089
USA


Yi Zhang
University of Southern California Keck School of Medicine
Los Angeles
California , 90089
USA


Sonya G. Fonseca
University of Massachusetts Medical School
Worcester
MA , 01605
USA


A.K. Walker
Howard Florey Institute University of Melbourne
Parkville
Victoria , 3010
Australia


B.J. Turner
Howard Florey Institute University of Melbourne
Parkville
Victoria , 3010
Australia


Eriko Fujita
Divisions of Development and Differentiation Department of Human Inherited Metabolic Disease
National Institute of Neuroscience
4-1-1 Ogawahigashi-machi
Kodaira
Tokyo , 87-8502
Japan


Hideki Nishitoh
Graduate School of Pharmaceutical Sciences
The University of Tokyo
Tokyo , 113-0033
Japan


Hisae Kadowaki
Graduate School of Pharmaceutical Sciences
The University of Tokyo
Tokyo, 113-0033
Japan


Kohsuke Takeda
Graduate School of Pharmaceutical Sciences
The University of Tokyo
Tokyo , 113-0033
Japan


Catalina Grabowski
Centro de Envejecimiento y Regeneración (CARE) Facultad de Ciencias Biológicas
Pontificia Universidad Católica de Chile
Santiago
Chile


Macarena Arrázola
Centro de Envejecimiento y Regeneración (CARE) Facultad de Ciencias Biológicas
Pontificia Universidad Católica de Chile
Santiago
Chile


Lorena Varela-Nallar
Centro de Envejecimiento y Regeneración (CARE) Facultad de Ciencias Biológicas
Pontificia Universidad Católica de Chile
Santiago
Chile


Enrique M. Toledo
Centro de Envejecimiento y Regeneración (CARE) Facultad de Ciencias Biológicas
Pontificia Universidad Católica de Chile
Santiago
Chile


Abhisek Mukherjee
Protein Misfolding Disorders Laboratory
George and Cynthia Mitchell Center for Neurodegenerative Diseases

/
Dept of Neurology
University of Texas Medical School at Houston
USA


Natalia B. Nedelsky
Department of Developmental Neurobiology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis
TN , 38120
USA




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