Editor: Tabish Qidwai

Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches

eBook: US $79 Special Offer (PDF + Printed Copy): US $126
Printed Copy: US $87
Library License: US $316
ISBN: 978-981-5040-92-0 (Print)
ISBN: 978-981-5040-91-3 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150409131220101

Introduction

This reference is the definitive guide to common neurodegenerative diseases that affect humans. The book covers mechanisms of some of the most well-known neurodegenerative diseases, their biomarkers, neuropharmacology, and emerging treatment strategies.

The book introduces the subject of neurodegeneration by outlining the biochemistry, pathophysiology and multifactorial neurological mechanisms (the role of genetics, environmental factors and mitochondrial damage, for example). Next, it explains some of the most studied diseases, namely, Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, and Multiple Sclerosis. Subsequent chapters delve into current knowledge about diagnostic and immunological biomarkers, followed by a summary of novel therapeutic strategies.

Special attention has been given to the role of medicinal plants in attempting to treat neurodegenerative diseases, as well as the public health burden posed by these conditions.

Key Features:

  • - give readers an overview of multifactorial disease mechanisms in neurodegeneration
  • - covers some major neurodegenerative diseases in detail
  • - covers diagnostic and immunological biomarkers
  • - explores current therapeutic strategies and drug targets in common neurodegenerative diseases
  • - offers a simple presentation with references for advanced readers

The book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.

Audience: Students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.

Preface

There are fourteen chapters in this book entitled " Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches." The book focuses on the current trends in pathophysiology, biomarkers, and therapeutic approaches for neurodegenerative diseases.

The goal of this book is to give readers an overview of multiple degenerative mechanisms in neurodegeneration, as well as biomarkers and therapeutic possibilities. The book is aimed to target students, research scholars, and neuro physicians who are interested in the topic. The book's structure is well-organized and updated.

This book is divided into three sections, each of which covers a different facet of the disease. Part I, which contains four chapters, is about multifactorial degenerative processes in neurodegenerative diseases; chapter 1 by Tabish Qidwai discusses multifactorial degeneration and the role of genetic and environmental factors in neurodegenerative diseases.

Sarika Singh et al. in chapter 2 outline the role of mitochondrial dysfunction. Chapter 3 by Mishra et al. presents the role of protein aggregation in neurodegenerative diseases. In chapter 4, Prakash et al., describe the reactive oxygen species in neurodegenerative diseases.

Part-II is focussed on pathophysiology, and biomarkers in neurodegenerative diseases. This part consists of six chapters; molecular biology, pathophysiology, and biomarkers of Parkinson's disease are discussed in chapter 5 by Arshad et al. In the chapter 6, Yadav et al., discuss the molecular basis, pathophysiology and biomarkers of Alzheimer's disease. Chapter 7 by Siddiqui reviews the molecular basis, pathophysiology and biomarker of Huntington's disease. Prakash et al., in chapter 8, describes the molecular biology, pathophysiology and biomarkers of multiple sclerosis. Chapter 9, by Subhadip Chakraborty, discusses the molecular diagnostics and immunological markers of neurodegenerative diseases. In chapter 10, Dinesh Yadav describes the omics approaches for biomarkers investigation in neurodegenerative diseases.

Part-III of the book covers the therapeutic approaches for neurodegenerative diseases, this part consists of four chapters; In Chapter 11, Rajesh Ugale focuses on emerging therapeutic approaches for neurodegenerative diseases. Chapter 12 by Singh et al., reviews the role of medicinal plants and natural compounds as antiparkinson agents. In chapter 13, Bandana outlines the neuropharmacology apporach in Alzheimer's and Huntington's disease. The last chapter by Vandana et al., describes the description of public health and the burden of neurodegenerative diseases.

This book, I believe, will be of tremendous interest to students, doctors, researchers, and even patients and their families. Finally, I would like to express my gratitude to all of the contributors to this book, as well as the Bentham Publishing Editorial Board for providing us with this invaluable opportunity.

Tabish Qidwai Faculty of Biotechnology
Shri Ramswaroop Memorial University
Lucknow-Deva road, U.P. India

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