Editor: Fernando A. Oliveira

Series Title: Recent Advances in Alzheimer Research

Cellular Mechanisms in Alzheimer’s Disease

Volume 2

eBook: US $129 Special Offer (PDF + Printed Copy): US $219
Printed Copy: US $155
Library License: US $516
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)
ISBN: 978-1-68108-716-0 (Print)
ISBN: 978-1-68108-715-3 (Online)
Year of Publication: 2018
DOI: 10.2174/97816810871531180201

Introduction

Alzheimer’s Disease (AD) is the product of the slow and progressive degenerative alteration that develops in the adult brain and can remain asymptomatic for a considerable time before cognitive deficits becomes evident. The main challenge for researchers is to identify markers of this degenerative process, and, in this sense, data has been generated through experiments bringing to light new mechanisms and hypothesis to explain its pathophysiology.

This book is a review of recent studies in AD molecular biology. Chapters explain various facets of AD, which include animal models, morphological changes, membrane composition, amyloidogenic peptides, intracellular transport systems, and the role of oxidative stress and calcium deregulation.

Readers will understand the molecular mechanisms behind AD and therefore broaden their perspective on this neurodegenerative disease and its progression.

Foreword

- Pp. i-ii (2)
Matthew Holahan

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Preface

- Pp. iii
Fernando A. Oliveira

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List of Contributors

- Pp. iv
Fernando A. Oliveira

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Differences and Implications of Animal Models for the Study of Alzheimerʼs Disease

- Pp. 1-40 (40)
Marcela Bermudez Echeverry, Sonia Guerrero Prieto, Joao Carlos dos Santos Silva, Maria Camila Almeida and Daniel Carneiro Carrettiero

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Micro and Macro Morphologic Changes in Alzheimer’s Disease

- Pp. 41-74 (34)
Daniel Moreira-Silva, Samanta Rodrigues and Tatiana L. Ferreira

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Alterations of Membrane Composition in Alzheimer´s Disease

- Pp. 75-103 (29)
Manoel Arcisio-Miranda, Rolf Matias Paninka and Luisa Ribeiro-Silva

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Amyloidogenic Peptide Structure, Aggregation, And Membrane Interaction

- Pp. 104-139 (36)
Manoel Arcisio-Miranda and Laíz da Costa Silva-Gonçalves

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Intracellular Transport System in AD

- Pp. 140-171 (32)
Merari F.R. Ferrari

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Alzheimer's Disease and Oxidative Stress

- Pp. 172-201 (30)
Andrea R. Vasconcelos, Paula F. Kinoshita, Cristoforo Scavone and Elisa M. Kawamoto

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Calcium Deregulation in Alzheimer’s Disease

- Pp. 202-215 (14)
Vitor S. Alves, Fernanda L. Ribeiro, Daniela R. de Oliveira and Fernando A. Oliveira

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Subject Index

- Pp. 215-223 (9)
Fernando A. Oliveira

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