Editor: Takanori Kawaguchi

Cancer Metastasis and Cancer Stem Cell/Niche

eBook: US $49 Special Offer (PDF + Printed Copy): US $113
Printed Copy: US $89
Library License: US $196
ISBN: 978-1-68108-348-3 (Print)
ISBN: 978-1-68108-347-6 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810834761160101

Introduction

A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches.

Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells in the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis.

This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.

Indexed in: Book Citation Index, Science; BIOSIS Previews, EBSCO.

Contributors

Editor(s):
Takanori Kawaguchi
Division of Human Life Sciences
Fukushima Medical University School of Nursing
Fukushima
Japan
/
Department of Pathology
General Aizu Chuo Hospital
Fukushima
Japan




Contributor(s):
Atsuko Deguchi
Department of Pharmacology
Tokyo Women’s Medical University
Tokyo
Japan


Bi-He Cai
The Institute of Biomedical Sciences (IBMS)
Academia Sinica
Taipei
Taiwan


Danny R. Welch
Department of Cancer Biology
The University of Kansas Medical Center
Kansas
USA
/
Department of Pathology and Laboratory Medicine
University of Kansas Medical Center
Kansas
USA
/
The University of Kansas Cancer Center
Kansas
USA


Dorcas A. Annan
Vascular Biology, Frontier Research Unit
Institute for Genetic Medicine, Hokkaido University
Sapporo
Japan


Eric D. Young
Department of Cancer Biology
The University of Kansas Medical Center
Kansas
USA


Fariba Behbod
Department of Cancer Biology
The University of Kansas Medical Center
Kansas
USA
/
Department of Pathology and Laboratory Medicine
University of Kansas Medical Center
Kansas
USA
/
The University of Kansas Cancer Center
Kansas
USA


Hsiang-Chi Huang
The Institute of Biomedical Sciences (IBMS)
Academia Sinica
Taipei
Taiwan


Keiichiro Sakuma
Division of Molecular Pathology
Aichi Cancer Center
Nagoya
Aichi
Japan


Koji Morimoto
Department of Hepato-Biliary-Pancreatic Surgery
Osaka National Hospital
Osaka
Japan
/
Osaka Women's Junior College
Osaka
Japan


Kyoko Hida
Vascular Biology, Frontier Research Unit
Institute for Genetic Medicine, Hokkaido University
Sapporo
Japan


Linheng Li
Department of Cancer Biology
The University of Kansas Medical Center
Kansas
USA
/
Stowers Institute for Medical Research (SIMR)
Missouri
USA
/
The University of Kansas Cancer Center
Kansas
USA


Nako Maishi
Vascular Biology, Frontier Research Unit
Institute for Genetic Medicine, Hokkaido University
Sapporo
Japan


Reiji Kannagi
The Institute of Biomedical Sciences (IBMS)
Academia Sinica
Taipei
Taiwan
/
Advanced Medical Research Center
Aichi Medical University
Nagakute
Aichi
Japan


Shoji Nakamori
Department of Hepato-Biliary-Pancreatic Surgery
Osaka National Hospital
Osaka
Japan


Takeshi Tomita
Department of Pharmacology
Tokyo Women’s Medical University
Tokyo
Japan


Yasuhiro Hida
Department of Cardiovascular and Thoracic Surgery
Hokkaido University Graduate School of Medicine
Sapporo
Japan


Yoshiro Maru
Department of Pharmacology
Tokyo Women’s Medical University
Tokyo
Japan




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