Editor: Takanori Kawaguchi

Cancer Metastasis and Cancer Stem Cell/Niche

eBook: US $49 Special Offer (PDF + Printed Copy): US $113
Printed Copy: US $89
Library License: US $196
ISBN: 978-1-68108-348-3 (Print)
ISBN: 978-1-68108-347-6 (Online)
Year of Publication: 2016
DOI: 10.2174/97816810834761160101


A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches.

Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells in the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis.

This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.

Indexed in: Book Citation Index, Science; BIOSIS Previews, EBSCO.


A malignant tumor is an actively growing tissue, composed of cells derived from a single cell that has undergone abnormal irreversible differentiation. These cells have two fundamental qualities: invasion and metastasis that induce the risk of cancer. Interestingly, recent researchers suggest that a malignant tumor is originated from cancer stem cells (CSC) accompanied with the niches. In this eBook, I would like to ask how the invasion and metastasis of cancer cells are explained by CSC theory and/or niche theory. The major points are as follows.

  1. The fundamental aspects of cancer:
    1. The first point of discussion is about the CSC/ niche in carcinoma in situ lesion which appears in various types of cancer including breast and bladder cancers. Where is the niche corresponding to CSC in the above situation and what is the role of the niche in cancer progression?
    2. Cancer metastasis involves two characteristic occurrences: “organ preference metastasis” and “metastatic potential”. Can these metastatic characteristics be explained by CSC /niche theory well?
  2. Metastatic phenotypes:
    • The mechanisms of cancer metastasis include non-invasiveness (carcinoma in situ), lateral/side invasion, stromal invasion, intravasation, circulation, arrest, attachment, extravasation, early growth, growth, and sometimes secondary/tertiary metastasis. This is followed by cellular/molecular mechanisms including cellular adhesion molecules such as carbohydrates, chemotactic activity by producing pseudopodia and invadopodia, deformability/plasticity and cytostreaming of metastatic cancer cells, and survival of metastatic cancer cells in floating (substrate-independent condition). Can these phenotypes of metastatic cancer cells be explained by cancer stem cell theory?
  3. The goal of this study is clinical application of the knowledge obtained by CSC/niche theory. CSC/niche targets have important therapeutic implications. The role of CSC/ niche on therapies for the prevention, maintenance therapy, personalized care, and perhaps even integrative care of cancer will be discussed.

Takanori Kawaguchi
Division of Human Life Sciences
Fukushima Medical University School of Nursing
Fukushima, Japan
Department of Pathology
General Aizu Chuo Hospital
Fukushima, Japan


I make a grateful acknowledgement for Mrs. Michiko Hoshi, who works in preparation of this book.


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