Editor: "Feng R. Tang"

Chemical-Induced Seizures: Mechanisms, Consequences and Treatment

Personal Book: US $24 Special Offer (PDF + Printed Copy): US $100
Printed Copy: US $89
Library Book: US $96
ISBN: 978-1-60805-600-2
eISBN: 978-1-60805-274-5 (Online)
DOI: 10.2174/97816080527451110101

Introduction

Since the Tokyo Sarin Subway Attack, the threat of chemical warfare agents has migrated from the battlefield to become a major concern for homeland security in the 21st century. While current fielded antidotes are able to mitigate acute high mortality arising from exposure to nerve agents, achieving effective neuroprotection in subjects with nerve agent induced prolonged seizures or status epilepticus is currently lacking. To overcome this challenge, establishing an improved understanding on the mechanism linking seizure onset during chemical (including nerve agents) poisoning to the subsequent cascade of biochemical, neurotoxicological, pathophysiological, genomic and behavioral changes post exposure is vital. Due to ethical, safety and chemical surety related issues, looking for surrogate chemicals has also become important for chemical defense research. In this book, internationally well-known clinicians and basic research scientists with expertise on chemical-induced seizures will update readers on the relevant areas. Doctors (civil and military), paramedics and medical students will find this book informative and timely for the current battle against asymmetric terrorist conflicts.

Indexed in: Web of Science, Scopus, Chemical Abstracts, EBSCO

Contributors

Editor(s):
Feng R. Tang

National University of Singapore
Singapore




Co-Editor(s):
Weng Keong Loke

Defence Medical and Environmental Research Institute
Singapore




Contributor(s):
Rezzan Gülhan Aker
Department of Pharmacology and Clinical Pharmacology
Marmara University School of Medicine
Istanbul
Turkey


Sergei Bankoul
Swiss Armed Forces, Office of the Surgeon in Chief
Ittigen, 3063 Switzerland, and Swiss Armed Forces
NBC Centre of Competence
Spiez, 3700



Christophe Baumberger
Swiss Armed Forces
NBC Centre of Competence
Spiez, 3700
Switzerland


Ron Ben-Abraham
Post Anesthesia Care Unit and Animal Research Laboratory
Tel Aviv Sourasky Medical Center, and the Sackler Faculty of Medicine
Tel Aviv University
Tel Aviv
Israel


Pierre-Nicolas Carron
Emergency Service
University Hospital (CHUV)
Lausanne, 1011
Switzerland


Oleg Dolkart
Post Anesthesia Care Unit and Animal Research Laboratory
Tel Aviv Sourasky Medical Center, and the Sackler Faculty of Medicine
Tel Aviv University
Tel Aviv
Israel


Adam-Scott Feiner
Emergency Service
University Hospital (CHUV), Lausanne
Switzerland


Lai Kwan Ho
Defence Medical and Environmental Research Institute
DSO National Laboratories
11 Stockport Road
Singapore


Stefanos N. Kales
Harvard Medical School & Harvard School of Public Health
Medical Director, Employee & Industrial Medicine, Cambridge Health Alliance
1493 Cambridge Street, Macht Bldg, The Cambridge Hospital Room 427
Cambridge
MA, 02139
United States


Koichi Kato
Department of Neurosurgery
Tokyo Rosai Hospital
Address correspondence to: Dr. Koichi Kato, 4-13-21 Omoriminami
Ota-ku
Tokyo, 143-0013
Japan


Demet Kinay
I. Neurology Clinic
Bakirköy Research Hospital for Neurology
Neurosurgery and Psychiatry
Istanbul
Turkey


Marloes J.A. Joosen
TNO Defence, Security and Safety
Department of Chemical Toxicology
Lange Kleiweg 137
Rijswijk, 2288GJ
The Netherlands


Ernest C. Lee
Harvard School of Public Health
, Senior Medical Officer, Occupational Health Detachment
Marine Corps Logistics Base Barstow
Bldg 149 James L Day St
Barstow
CA, 92311
United States


Weng Keong Loke
Defence Medical and Environmental Research Institute
DSO National Laboratories
11 Stockport Road
Singapore 117605


Filiz Yilmaz Onat
Department of Pharmacology and Clinical Pharmacology
Marmara University School of Medicine
Istanbul
Turkey


August B. Smit
Center for Neurogenomics and Cognitive Research
Free University
De Boelelaan 1085, 1081HV
Amsterdam
The Netherlands


Andreas Stettbacher
Swiss Armed Forces
Office of the Surgeon in Chief
Ittigen, 3063
Switzerland


Feng Ru Tang
Temasek Laboratories
National University of Singapore
5A, Engineering Drive 1
Singapore 117411
/
Department of Anatomy
Yong Loo Lin School of Medicine
Block MD 10, National University of Singapore
4 Medical Drive
Singapore


Marcel J. van der Schans
TNO Defence, Security and Safety
Department of Chemical Toxicology
Lange Kleiweg 137, 2288GJ
Rijswijk
The Netherlands


Herman P.M. van Helden
TNO Defence, Security and Safety
Department of Chemical Toxicology
Lange Kleiweg 137, 2288GJ
Rijswijk
The Netherlands


Avi A Weinbroum
Post Anesthesia Care Unit and Animal Research Laboratory
Tel Aviv Sourasky Medical Center, and the
Sackler Faculty of Medicine, Tel Aviv University
Tel Aviv
Israel


Bertrand Yersin
Emergency Service
University Hospital (CHUV)
Lausanne, 1011
Switzerland




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