Editor: "Teodorico C. Ramalho"

Chemoinformatics: Directions Toward Combating Neglected Diseases

Personal Book: US $39 Special Offer (PDF + Printed Copy): US $138
Printed Copy: US $119
Library Book: US $156
ISBN: 978-1-60805-502-9
eISBN: 978-1-60805-183-0 (Online)
DOI: 10.2174/97816080518301120101

Introduction

Low-income populations in developing regions of Africa, Asia and the Americas have been particularly injured by a group of tropical infections denominated neglected diseases. Compared to important illnesses, neglected diseases do not enjoy significant research funding and are not considerably important targets for the “Big Pharma” ventures in terms of development of new drugs, though these infections can make widespread diseases like AIDS more deadly. Despite affecting millions of people around the world, causing many deaths and having a significant limiting influence on the quality of life of affected people, the selection of new molecular targets and the development of more efficient drugs against those diseases is scarce. Furthermore, little detailed computational work on this subject has appeared. It should be kept in mind, however, that computers are an essential tool in modern medicinal chemistry. Currently, these powerful computational tools allow one to obtain insights on the interaction between enzyme-substrate, reaction mechanisms, statistical behavior of molecules and much more, at the molecular level, contributing significantly to solve problems in biological systems. Chemoinformatics: Directions Toward Combating Neglected Diseases explores an open problem in academic literature with a stimulating discussion on the state of the art knowledge in this important research field with respect to neglected diseases, pointing out perspectives on using molecular modeling and theoretical approaches. This eBook is a handy reference guide for anyone who is interested in or deals with medicinal chemistry focused on neglected diseases, from students to advanced researchers.

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

Contributors

Editor(s):
Teodorico C. Ramalho
Universidade Federal de Lavras, Federal University of Lavras - UFLA
Brazil




Co-Editor(s):
Matheus P. Freitas
Federal University of Lavras - UFLA
Brazil


Elaine F. F. da Cunha
Universidade Federal de Lavras, Federal University of Lavras - UFLA
Brazil




Contributor(s):
Teodorico C. Ramalho
Department of Chemistry
Federal University of Lavras
P.O. Box 3037
Lavras
MG, 37200-000
Brazil


Matheus P. Freitas
Department of Chemistry
Federal University of Lavras
P.O. Box 3037
Lavras
MG, 37200-000
Brazil


Elaine F. F. da Cunha
Department of Chemistry
Federal University of Lavras
P.O. Box 3037
Lavras
MG, 37200-000
Brazil


Daiana Teixeira Mancini
Department of Chemistry
Federal University of Lavras
P.O. Box 3037
Lavras
MG, 37200-000
Brazil


Rodrigo A. Cormanich
Chemistry Institute, State University of Campinas
P.O. Box 6154
Campinas
SP, 13083-970
Brazil


Alicia Ponte-Sucre
Laboratory of Molecular Physiology, Institute of Experimental Medicine, Faculty of Medicine
Universidad Central de Venezuela
Caracas, 85100
Venezuela


Emilia Díaz
Laboratory of Molecular Physiology, Institute of Experimental Medicine, Faculty of Medicine
Universidad Central de Venezuela
Caracas, 85100
Venezuela


Maritza Padrón-Nieves
Laboratory of Molecular Physiology, Institute of Experimental Medicine, Faculty of Medicine
Universidad Central de Venezuela
Caracas, 85100
Venezuela


Tanos C. C. França
Chemical Engineering Department
Military Institute of Engineering, Pça General Tibúrcio
80 – Urca, 22290-270, Rio de Janeiro/RJ
Rio de Janeiro
Brazil


Magdalena Nascimento Rennó
Universidade Federal do Rio de Janeiro - Campus Macaé
Rua Aloísio da Silva Gomes, nº 50, Granja dos Cavaleiros
Macaé
RJ, CEP: 27930-560
Brazil


Mushtaque S. Shaikh
Department of Pharmaceutical Chemistry
Bombay College of Pharmacy, Kalina, Santacruz (E)
Mumbai, 400 098
India


Vijay M. Khedkar
Department of Pharmaceutical Chemistry
Bombay College of Pharmacy, Kalina, Santacruz (E)
Mumbai, 400 098
India


Evans C. Coutinho
Department of Pharmaceutical Chemistry
Bombay College of Pharmacy, Kalina, Santacruz (E)
Mumbai, 400 098
India


Alan Wilter Sousa da Silva
Department of Biochemistry
University of Cambridge
80 Tennis Court Road
UK


Adriana de Oliveira Gomes
Laboratório de Modelagem Molecular e QSAR (ModMolQSAR)
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro
Rio de Janeiro
RJ
Brazil


Alessandra Mendonça Teles de Souza
Laboratório de Modelagem Molecular e QSAR (ModMolQSAR)
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro
Rio de Janeiro
RJ
Brazil


Alice Maria Rolim Bernardino
Laboratório de Modelagem Molecular e QSAR (ModMolQSAR)
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro
Rio de Janeiro
RJ
Brazil


Helena Carla Castro
Laboratório de Modelagem Molecular e QSAR (ModMolQSAR)
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro
Rio de Janeiro
RJ
Brazil


Carlos Rangel Rodrigues
Laboratório de Modelagem Molecular e QSAR (ModMolQSAR)
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro
Rio de Janeiro
RJ
Brazil


Carlton Anthony Taft
Centro Brasileiro de Pesquisas Físicas
Rua Dr. Xavier Sigaud, 150, Urca
Rio de Janeiro, 22290-180
Brazil


Carlos Henrique Tomich de Paula da Silva
School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo
Ribeirão Preto, 14040-903
Brazil




RELATED BOOKS

.Advances in Combinatorial Chemistry & High Throughput Screening.