Editor: Rathnam Chaguturu

Advances in Combinatorial Chemistry & High Throughput Screening

Volume 1

eBook: US $89 Special Offer (PDF + Printed Copy): US $176
Printed Copy: US $131
Library License: US $356
ISSN: 2589-2835 (Print)
ISSN: 2214-515X (Online)
ISBN: 978-1-60805-746-7 (Print)
ISBN: 978-1-60805-745-0 (Online)
Year of Publication: 2013
DOI: 10.2174/97816080574501130101

Introduction

Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). A wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers – including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.

Foreword

- Pp. i-ii (2)
Haian Fu
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Preface

- Pp. iii-iv (2)
Rathnam Chaguturu
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List of Contributors

- Pp. v-vii (3)
Rathnam Chaguturu
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Assessing Chemicals Using Partial Order Ranking Methodology

- Pp. 3-35 (33)
Lars Carlsen

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Building a Chemical Space Based on Fragment Descriptors

- Pp. 36-59 (24)
Igor I. Baskin, Alexandre Varnek

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Fluorescent Probes for Cellular Assays

- Pp. 60-83 (24)
George T. Hanson, Bonnie J. Hanson

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Label-Free Cell Phenotypic GPCR Drug Discovery

- Pp. 84-129 (46)
Ye Fang
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Immunological Assays: Biotools for High Throughput Screening and Characterisation of Combinatorial Libraries

- Pp. 130-158 (29)
Maria Â. Taipa

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Screening and Mechanism-Based Evaluation of Estrogenic Botanical Extracts

- Pp. 159-186 (28)
Cassia R. Overk, Judy L. Bolton

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A Homogeneous Platform to Discover Inhibitors of the GoLoco Motif/G-alpha Interaction

- Pp. 187-218 (32)
Adam J. Kimple, Adam Yasgar, Mark Hughes, Ajit Jadhav, Francis S. Willard, Robin E. Muller, Christopher P. Austin, James Inglese, Gordon C. Ibeanu, David P. Siderovski, Anton Simeonov

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G-Protein Activation State-Selective Binding Peptides as New Tools for Probing Heterotrimeric G-protein Subunit Signaling Dynamics

- Pp. 219-247 (29)
Christopher A. Johnston, Francis S. Willard, Kevin Ramer, Rainer Blaesius, Natalia Roques, David P. Siderovski

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Index

- Pp. 248-258 (11)
Rathnam Chaguturu
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