Editor: "Rathnam Chaguturu"

Advances in Combinatorial Chemistry & High Throughput Screening

Volume 1

Personal Book: US $89 Special Offer (PDF + Printed Copy): US $163
Printed Copy: US $119
Library Book: US $356
ISSN: 2589-2835
eISSN: 2214-515X (Online)
ISBN: 978-1-60805-746-7
eISBN: 978-1-60805-745-0 (Online)
DOI: 10.2174/97816080574501130101

Introduction

Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). A wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers – including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.

Foreword

- Pp. i-ii (2)
Haian Fu
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Preface

- Pp. iii-iv (2)
Rathnam Chaguturu
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List of Contributors

- Pp. v-vii (3)
Rathnam Chaguturu
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Assessing Chemicals Using Partial Order Ranking Methodology

- Pp. 3-35 (33)
Lars Carlsen

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Building a Chemical Space Based on Fragment Descriptors

- Pp. 36-59 (24)
Igor I. Baskin and Alexandre Varnek

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Fluorescent Probes for Cellular Assays

- Pp. 60-83 (24)
George T. Hanson and Bonnie J. Hanson

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Label-Free Cell Phenotypic GPCR Drug Discovery

- Pp. 84-129 (46)
Ye Fang
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Immunological Assays: Biotools for High Throughput Screening and Characterisation of Combinatorial Libraries

- Pp. 130-158 (29)
Maria Â. Taipa

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Screening and Mechanism-Based Evaluation of Estrogenic Botanical Extracts

- Pp. 159-186 (28)
Cassia R. Overk and Judy L. Bolton

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A Homogeneous Platform to Discover Inhibitors of the GoLoco Motif/G-alpha Interaction

- Pp. 187-218 (32)
Adam J. Kimple, Adam Yasgar, Mark Hughes, Ajit Jadhav, Francis S. Willard, Robin E. Muller, Christopher P. Austin, James Inglese, Gordon C. Ibeanu, David P. Siderovski and Anton Simeonov

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G-Protein Activation State-Selective Binding Peptides as New Tools for Probing Heterotrimeric G-protein Subunit Signaling Dynamics

- Pp. 219-247 (29)
Christopher A. Johnston, Francis S. Willard, Kevin Ramer, Rainer Blaesius, Natalia Roques and David P. Siderovski

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Index

- Pp. 248-258 (11)
Rathnam Chaguturu
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