Editor: Liang Qiao

Molecular Aspects of Hepatocellular Carcinoma

eBook: US $99 Special Offer (PDF + Printed Copy): US $168
Printed Copy: US $119
Library License: US $396
ISBN: 978-1-60805-378-0 (Print)
ISBN: 978-1-60805-072-7 (Online)
Year of Publication: 2012
DOI: 10.2174/97816080507271120101


Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. It should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.


The incidence of hepatocellular carcinoma (HCC) is rising in many Western countries, but has always been high in Eastern countries. Much of the knowledge that we have about HCC was developed in Asia, particularly in Japan. However, the majority of all HCCs that develop each year arises in China. Over many years of Western medicine, studies from China have not been major contributors. In part, no doubt this was due to restrictions before China opened up to the West, in part to language difficulties, and in part because of a lack of a Western scientific tradition. Of course, this is all changing, and more and more articles in the medical literature are from China. It is appropriate therefore that many of the contributors to the volume on hepatocellular carcinoma are from China, and that Chinese authors are contributing to the solutions to what is a major Chinese problem. In so doing, they also inform those of us in the West who deal with this disease. Just as in the past we have learned from our Japanese colleagues, so we will in future learn from our Chinese colleagues. This book is an excellent start in that direction.

The editors are to be congratulated on persuading such a distinguished panel of authors to contribute to this volume. Many of the authors are well known not only in China, but also elsewhere in Asia and in the West. It has been my personal pleasure to meet a number of these authors.

This book differs from other volumes on HCC that have been published in the recent past in the choice of topics, which reflect a much more experimental emphasis, and a strong emphasis on scientific discovery and analysis. As a Westerner I find the choice of topics no less refreshing than the choice of authors. This book has much to teach us, and I expect that it will be widely read.

Morris Sherman
Associate Professor of Medicine
Chairman, Canadian Viral Hepatitis Network and Canadian Liver Foundation
University of Toronto and Toronto General Research Institute