Author: Lawrence M. Agius

Hypotheses and Dynamics in the Pathogenesis of Neurodegenerative Disorders

eBook: US $39 Special Offer (PDF + Printed Copy): US $99
Printed Copy: US $80
Library License: US $156
ISBN: 978-1-60805-034-5 (Print)
ISBN: 978-1-60805-032-1 (Online)
Year of Publication: 2009
DOI: 10.2174/97816080503211090101

Introduction

This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. The book includes a critical reappraisal of lesions in conditions such as Alzheimer's disease. Common disorders such as cardiovascular disease appear to be prime inducing agents in neurodegenerative diseases. These observations should help researchers to reevaluate the investigative approach towards diseases of the central nervous system. The style follows the current text adopted by morphologists in terms that allow for further investigation by research workers. The text represents an attempt to generate a refreshing viewpoint of end stage CNS disorders that follow a long pre-clinical pathogenic course implicating common generically related and interacting etiologic agents. This book is meant to be a useful guide for researchers and clinicians interested in the development and treatment of CNS disorders.

Preface

- Pp. i
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SPECIFICS OF DYNAMICS OF ALZHEIMER DISEASE

- Pp. 1-12 (12)
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DEFINING PARAMETERS OF NEURODEGENERATION

- Pp. 13-19 (7)
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PATHOGENESIS OF DISEASE COURSE IN NEURODEGENERATION

- Pp. 20-35 (16)
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ETIOLOGY ATTRIBUTES OF DISEASE PROGRESSION

- Pp. 36-46 (11)
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DIMENSIONS OF GLOBAL BRAIN INVOLVEMENT

- Pp. 47-56 (10)
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AGING AND NEURODEGENERATION

- Pp. 57-70 (14)
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REGIONAL DISTRIBUTION OF LESIONS

- Pp. 71-76 (6)
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GLIAL-NEURONAL COMPARTMENTS

- Pp. 77-85 (9)
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References

- Pp. 86-90 (5)
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Index

- Pp. 91-95 (5)
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