Editor: "Malay Chatterjee"

Angiogenesis & Therapeutic Targets In Cancer

Personal Book: US $44 Special Offer (PDF + Printed Copy): US $140
Printed Copy: US $119
Library Book: US $176
ISBN: 978-1-60805-573-9
eISBN: 978-1-60805-007-9 (Online)
DOI: 10.2174/97816080500791100101

Introduction

Angiogenesis plays rate limiting roles in tumor growth and invasion. Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. This book covers different therapeutic targets for angiogenesis interventions with emphasis on clinical development of antiangiogenic drugs that target antiangiogenic cascade in different forms of cancers like breast cancer, multiple myeloma, renal carcinoma, gastrointestinal, prostate and lung cancer. Surrogate predictive markers of antiangiogenic therapy in novel preclinical models recapitulating tumor microenvironment together with genomic studies are special features of this book. Gene therapy approaches with emphasis on viral vectors have been explored in preclinical model with direct and indirect angiogenesis inhibitors. Recent advances in clinical application with antiangiogenic therapy resulted in encouraging clinical results are also detailed. It includes chapters that bridge the gap between basic science and clinical application of current knowledge of cancer. Different chapters are contributed by distinguished scientists and clinicians around the world making it an important addition to the bookshelves of clinicians, academics, researchers, students and institutions.

Foreword

In 1889, Dr. Stephen Paget investigated the pattern of metastasis in over 700 patients with a variety of cancers. From his studies he concluded that the process of metastasis [1] was not random but rather regulated by a proper interplay between the cancer cells (seed) and the organ microenvironment (soil) of the host. His "seed and soil" hypothesis laid one of the major milestones in the biology of cancer metastasis. That was largely forgotten for over 100 years until Dr. Isaiah J. Fidler awaken Dr. Paget's work and fortified the "seed and soil" hypothesis [2] with three crucial principles: (1) neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties; (2) the process of metastasis is selective for cells that succeed in invasion, embolization, survival in the circulation, arrest in a distant capillary bed, and extravasation into and multiplication within the organ parenchyma; and (3) the outcome of metastasis depends on multiple interactions ("cross-talk") of metastatic cells with homeostatic mechanisms, which the tumor cells can usurp. Dr. Fidler further gave emphasis to the principle that therapy of metastasis can be targeted not only against tumor cells but also against the homeostatic factors that promote tumor cell growth, survival, angiogenesis, invasion, and metastasis. These seminal concepts, together with Dr. Judah Folkman's shaping statement in 1971 that all cancer tumors are angiogenesis-dependent, defined the fields of cancer metastasis and angiogenesis [3]

It is indeed my great pleasure to prologue the making of the monogram "Angiogenesis and Therapeutic Targets in Cancer" organized and edited by Professor Malay Chatterjee. This book encompasses many important areas in the therapy of cancer by targeting various parameters of the angiogenesis process, such as angiogenesis inhibitors, dietary agents that affect angiogenesis, molecular markers for therapy, microenvironment, receptor tyrosine kinases, and signal transduction pathways; of the breast, gastric, lung, prostate, renal cancers as well as Schwannoma and multiple myeloma. I look forward to a stimulating monogram and a successful press.

I hold in true and wish therefore to share in this monogram my personal principle that "for tumor progression and cancer metastasis are not random - treatments and cure is logical and eventual".

Dominic Fan
The University of Texas
M.D. Anderson Cancer Center
Houston, Texas

REFERENCES

[1] Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1:571-573, 1889.

[2] Fidler I. J. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited (Timeline). Nat. Rev. Cancer 3:3453-3458, 2003.

[3] Folkman J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285:1182-1186. 1971.


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