Editor: Malay Chatterjee

Angiogenesis & Therapeutic Targets In Cancer

eBook: US $44 Special Offer (PDF + Printed Copy): US $140
Printed Copy: US $119
Library License: US $176
ISBN: 978-1-60805-573-9 (Print)
ISBN: 978-1-60805-007-9 (Online)
Year of Publication: 2010
DOI: 10.2174/97816080500791100101

Introduction

Angiogenesis plays rate limiting roles in tumor growth and invasion. Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. This book covers different therapeutic targets for angiogenesis interventions with emphasis on clinical development of antiangiogenic drugs that target antiangiogenic cascade in different forms of cancers like breast cancer, multiple myeloma, renal carcinoma, gastrointestinal, prostate and lung cancer. Surrogate predictive markers of antiangiogenic therapy in novel preclinical models recapitulating tumor microenvironment together with genomic studies are special features of this book. Gene therapy approaches with emphasis on viral vectors have been explored in preclinical model with direct and indirect angiogenesis inhibitors. Recent advances in clinical application with antiangiogenic therapy resulted in encouraging clinical results are also detailed. It includes chapters that bridge the gap between basic science and clinical application of current knowledge of cancer. Different chapters are contributed by distinguished scientists and clinicians around the world making it an important addition to the bookshelves of clinicians, academics, researchers, students and institutions.

Foreword

- Pp. i
Dominic Fan
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Preface

- Pp. ii-iii (2)
Jaak Ph. Janssens
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Acknowledgement

- Pp. iv
Malay Chatterjee
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Contributors

- Pp. v-viii (4)
Malay Chatterjee, Ajay Rana and Basabi Rana
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Angiogenesis: Antiangiogenesis Strategy and Angiogenesis Inhibitors

- Pp. 1-17 (17)
Theodora Kerenidi and Kostas Syrigos

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Angiogenesis and Gastrointestinal Cancer

- Pp. 18-30 (13)
Ellen Kossoff and Wen W. Ma

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Breast Cancer Prevention and Treatment with Dietary Agents Affecting Angiogenesis: Progress and Promise

- Pp. 31-44 (14)
Anupam Bishayee

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Angiogenesis in Cancer: Therapeutic Targets and Angiogenesis Inhibitors

- Pp. 45-67 (23)
Ana R. Quesada and Miguel Angel Medina

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Angiogenesis in Breast Cancer: Molecular Markers, Therapeutic Targets, Antiangiogenic Therapy & Inhibitors

- Pp. 68-89 (22)
Carmen Silvia Passos Lima, Gustavo Jacob Lourenco and Jose Augusto Rinck Jr.

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Receptor Tyrosine Kinases in Human Schwannoma

- Pp. 90-98 (9)
C Oliver Hanemann and Sylwia Ammoun

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Angiogenesis and Lung Cancer: Antiangiogenic Agents and Therapy

- Pp. 99-134 (36)
Mai Har Sham and Kexia Cai

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Angiogenesis and Gastric Cancer: Molecular Pathways & Therapeutic Targets

- Pp. 135-146 (12)
C. Moser and O. Stoeltzing

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Angiogenesis and Breast Cancer: Targets and Therapies

- Pp. 147-164 (18)
S. Martin and H. Evans

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Translational Studies on the Bone Marrow Microenvironment in Multiple Myeloma: Experimental Models and Emerging Therapeutical Strategies

- Pp. 165-179 (15)
Pierfrancesco Tassone, Teresa Calimeri, Marco Rossi, Maria Teresa Di Martino, Paola Neri and Pierosandro Tagliaferri

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Targeted Therapy in Renal Cell Carcinoma

- Pp. 180-189 (10)
G. Gasparini and R. Longo

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Surrogate Markers of Antiangiogenic Therapies

- Pp. 190-208 (19)
Epie Boven, Martijn R. Meijerink and Laura Vroling

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TGF-β Signaling Dictates Apoptotic and Angiogenic Response During Prostate Cancer Progression

- Pp. 209-218 (10)
Natasha Kyprianou and Joanne Collazo

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Index

- Pp. 219-225 (7)
Malay Chatterjee, Ajay Rana and Basabi Rana
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