Editors: Bashir Matata, Maqsood Elahi, Priscilla Day-Walsh

Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease

eBook: US $49 Special Offer (PDF + Printed Copy): US $84
Printed Copy: US $59
Library License: US $196
ISBN: 978-981-5165-02-9 (Print)
ISBN: 978-981-5165-01-2 (Online)
Year of Publication: 2023
DOI: 10.2174/97898151650121230101

Introduction

Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease is an update on the recent advances in the development of antioxidant-based therapies. It starts with an overview of the mechanisms underlying the genesis of oxidative stress, summarizing the link between oxidative stress and a number of cardiovascular conditions. This is followed by an explanation of how oxidative stress interacts with lipid metabolism and the placental environment. Three chapters on the role of antioxidant-based therapy for cardiovascular diseases round up the book.

Key Features

  • - Outlines several cell-signaling pathways that are modulated by the interplay between reducing and oxidizing agents (redox status) and gene expression in the cardiovascular disease process
  • - Brings information about maternal programming environment in the placenta
  • - Covers development of novel nanotechnology-based antioxidant delivery systems for effective drug delivery
  • - Includes references for further reading

The book is aimed at a broad readership of scientific and medical professionals involved in research on cardiovascular diseases, pathophysiology, pharmacy, pharmaceutical science and life sciences. It also serves as a reference for scholars who want to understand the complex biochemical mechanisms of antioxidant agents.

Audience

Scientific and medical professionals involved in research on cardiovascular diseases, pathophysiology, pharmacy, pharmaceutical science and life sciences; scholars who want to understand the complex biochemical mechanisms of anti-oxidant agents.

Foreword

Oxidative stress is a major contributor to the pathology and pathophysiology of cardiovascular disease and other related human conditions; however, our understanding of the processes and mechanisms is still limited and warrants further studies and dissemination. Drs Elahi, Day-Walsh and Matata have undertaken a momentous task of assembling and organising topical and interesting topics for this book which starts with expositions in the basic science of Redox signaling, oxidative stress in cardiovascular disease (Bashir Matata & Maqsood Elahi), followed by oxidative stress and leukocytes activation (Bashir Matata & Maqsood Elahi). Dr. Priscilla Day-Walsh discusses the role of lipids and oxidation in cardiovascular disease which are hotly debated in the scientific community. Dr. Sferruzzi-Perri and colleagues elucidate the role of maternal factors in programming and progression of cardiovascular disease. The role of microbiomes in cardiovascular diseases (Day-Walsh & Shehata) has become a very important topic of research and medical practice which is a salient chapter of this book. The role of antioxidants in the modulation of inflammation and cardiovascular disease is explained in detail by Dr. Matata and Dr. Elahi. The last two chapters focus on therapeutic approaches focusing on oxidants, nitric oxide, role of nanotechnology (Gajardo et al. and Kogan et al. respectively) which advances our knowledge of their usefulness in clinical practice.

The authors of different chapters in this book are experts in their field at clinical and research levels and have crafted their chapters in a way that has appeal and usability at many levels for colleagues in clinical research, medical practice, and education (doctors, nurses and other health care practitioners). This book will serve as a treatise as an excellent update on the role of oxidation, oxidative stress, and antioxidants in cardiovascular disease and its prevention. Authors and Editors are congratulated to bring this important task and book to fruition.

Sarabjit Mastana
Senior Lecturer in Human Genetics
Human Genomics Lab
School of Sport, Exercise and Health Sciences
Loughborough University, Loughborough
LE11 3TU, UK