Editors: Dileep Kumar, Prashant Tiwari

Enzymatic Targets for Drug Discovery Against Alzheimer's Disease

eBook: US $49 Special Offer (PDF + Printed Copy): US $90
Printed Copy: US $65
Library License: US $196
ISBN: 978-981-5136-15-9 (Print)
ISBN: 978-981-5136-14-2 (Online)
Year of Publication: 2024
DOI: 10.2174/97898151361421230101

Introduction

The book summarizes the role of multiple enzyme targets and strategies to design and develop novel drug candidates for Alzheimer’s disease (AD). Insights from researchers across the globe from diverse fields are presented in a thematic volume.

The chapters highlight current information scientists have unraveled about the origin, pathogenesis and prevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment.

The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies.

Readership

Students and researchers in the field of neuroscience, medicine and pharmacology.

Foreword

It is my pleasure to write the foreword for this edited book titled “Enzymatic Targets for Drug Discovery against Alzheimer's Disease” by Dr. Dileep Kumar and his editorial team, which focuses on novel therapeutics and strategies for the treatment and/or management of Alzheimer's disease.

The book summarizes the role of multiple targets and strategies to design and develop novel drug candidates against both established and new drug targets viz., Tau, TREM, and Microglia.

The book highlights the current information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book is to capture and discuss improvements in both the diagnosis and potential treatment of AD by established and novel strategies. It brings researchers across the globe having a different scientific interests and expertise under one roof to specifically focus on AD.

The book will benefit not only students but researchers and avid readers around the globe to devour the nuances of AD in a simple yet lucid manner.

I wish all success to the editor Dr. Dileep Kumar and his team for their endeavor to fulfill this assiduous task. I sincerely believe that the book has been prepared with scientific skills and experimental details and will provide useful information to researchers.

Sushil K. Singh
Department of Pharmaceutical Engineering & Technology
IIT(BHU), Varanasi
India