Editors: Dileep Kumar, Prashant Tiwari

Enzymatic Targets for Drug Discovery Against Alzheimer's Disease

eBook: US $49 Special Offer (PDF + Printed Copy): US $90
Printed Copy: US $65
Library License: US $196
ISBN: 978-981-5136-15-9 (Print)
ISBN: 978-981-5136-14-2 (Online)
Year of Publication: 2024
DOI: 10.2174/97898151361421230101

Introduction

The book summarizes the role of multiple enzyme targets and strategies to design and develop novel drug candidates for Alzheimer’s disease (AD). Insights from researchers across the globe from diverse fields are presented in a thematic volume.

The chapters highlight current information scientists have unraveled about the origin, pathogenesis and prevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment.

The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies.

Readership

Students and researchers in the field of neuroscience, medicine and pharmacology.

Contributors

Editor(s):
Dileep Kumar
Department of Pharmaceutical Chemistry
Poona College of Pharmacy, Bharti Vidyapeeth
Pune, 411038,
India
Department of Entomology and Nematology
UC Davis Comprehensive Cancer Center
University of California Davis
CA 95616
USA


Prashant Tiwari
Department of Pharmacology
College of Pharmaceutical Sciences
Dayananda Sagar University
Bengaluru, 560111, Karnataka,
India




Contributor(s):
Atukuri Dorababu
SRMPP Government First Grade College
Huvinahadagali – 583219
India


Ayush Kumar
Department of Medicine
Tata Motors Hospital
Telco, Jamshedpur
831004 India


Achal Mishra
Faculty of Pharmaceutical Sciences
Shri Shankaracharya Group of Institutions
Junwan, Bhiali (CG)
India


Ahmet Ozan Ozgen
Department of Medicinal Biotechnology
Akdeniz University
Antalya
Turkey


Abha Deshpande
Poona College of Pharmacy
Bharati Vidyapeeth (Deemed to be) University
Pune, Maharashtra, 411038
India


Arvinder Kaur
Department of Pharmaceutics
KLE College of Pharmacy, Bengaluru
Constituent Unit of KLE Academy of Higher Education and Research
Belgavi, 590001
India


Chandraprabha Sahu
School of Engineering & IT
ARKA JAIN University, Gamharia
Seraikela Kharsawan
Jharkhand-832108, India


Divya Adiga
Department of Cell and Molecular Biology
Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE)
Manipal – 576104
Karnataka
India


Dileep Kumar
Department of Pharmaceutical Chemistry
Poona College of Pharmacy, Bharati Vidyapeeth
Pune, 411038
India
/
Department of Entomology and Nematology, UC Davis Comprehensive Cancer Center
University of California
Davis, CA 95616
USA


Dipanjan Karati
Department of Entomology and Nematology UC Davis Comprehensive Cancer Center
University of California Davis One Shields Avenue Davis
CA 95616
USA


Devyani Bhatnagar
Department of Pharmaceutical Chemistry
Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University)
Erandwane, Pune – 411038, Maharashtra
India


Deepa Bagur Parmesh
Department of Pharmaceutics
KLE College of Pharmacy, Bengaluru, Constituent Unit of KLE Academy of Higher Education and Research
Belgavi, 590001
India


Ekta Shirbhate
Institute of Pharmaceutical Sciences
Guru Ghasidas University
Bilaspur-495 009, (C.G.)
India


Gargi Digholkar
Poona College of Pharmacy
Bharati Vidyapeeth (Deemed to be) University
Pune, Maharashtra, 411038
India


Harish Rajak
Institute of Pharmaceutical Sciences
Guru Ghasidas University
Bilaspur-495 009, (C.G.)
India


Kavya Manjunath
Department of Pharmacology
KLE College of Pharmacy, Bengaluru, Constituent Unit of KLE Academy of Higher Education and Research
Belgavi, 590001
India


Khushboo Raj
School of Pharmacy
Arka Jain University, Jamshedpur
Jharkhand
832108 India


Manish Kumar Jeengar
School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus
AIMS Ponekkara P. O., Kochi
Kerala 682 041
India


Mahesh AR
Faculty of Pharmacy
M.S. Ramaiah University of Applied Sciences
Bengaluru-560054, Karnataka
India


Nadeem G. Khan
Department of Cell and Molecular Biology
Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE)
Manipal – 576104, Karnataka
India


Ozan Emre Eyupoglu
Department of Biochemistry
School of Pharmacy, Istanbul Medipol University
Istanbul
Turkey


Pankaj Kumar Singh
National Institute of Pharmaceutical and Education and Research
Hyderabad, India


Priya Tiwari
Institute of Pharmaceutical Sciences
Guru Ghasidas University
Bilaspur-495 009, (C.G.)
India


Rakesh Kore
Institute of Pharmaceutical Sciences
Guru Ghasidas University
Bilaspur-495 009, (C.G.)
India


Ravichandran Veerasamy
Faculty of Pharmacy
AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman
Malaysia


Ryan Varghese
Poona College of Pharmacy
Bharati Vidyapeeth (Deemed to be) University
Pune, Maharashtra, 411038
India


S. Sriharikrishnaa
Department of Cell and Molecular Biology
Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE)
Manipal – 576104
India


Sangavi Eswaran
Department of Cell and Molecular Biology
Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE)
Manipal – 576104, Karnataka
India


Shama Prasada Kabekkodu
Department of Cell and Molecular Biology
Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE)
Manipal – 576104, Karnataka
India


Shweta Shrivastava
School of Pharmacy, School of Health and Allied Sciences
ARKA JAIN University
Gamharia, Seraikela Kharsawan
Jharkhand-832108, India


Sonal Dubey
College of Pharmaceutical Sciences
Dayananda Sagar University, Kumaraswamy Layout
Bengaluru 560078, Karnataka
India


Shreya Ladhe
Department of Pharmaceutical Chemistry, Poona College of Pharmacy
Bharati Vidyapeeth (Deemed to be University)
Erandwane, Pune – 411038, Maharashtra
India


Shilpa Murthy
Department of Pharmaceutical Chemistry
KLE College of Pharmacy, Bengaluru, Constituent Unit of KLE Academy of Higher Education and Research
Belgavi, 590001
India


Vijay K Patel
Institute of Pharmaceutical Sciences
Guru Ghasidas University
Bilaspur-495 009, (C.G.)
India


Yogita Kumari
School of Pharmacy
Arka Jain University, Jamshedpur
Jharkhand
832108 India