Editors: Dileep Kumar, Prashant Tiwari

Enzymatic Targets for Drug Discovery Against Alzheimer's Disease

eBook: US $49 Special Offer (PDF + Printed Copy): US $90
Printed Copy: US $65
Library License: US $196
ISBN: 978-981-5136-15-9 (Print)
ISBN: 978-981-5136-14-2 (Online)
Year of Publication: 2024
DOI: 10.2174/97898151361421230101

Introduction

The book summarizes the role of multiple enzyme targets and strategies to design and develop novel drug candidates for Alzheimer’s disease (AD). Insights from researchers across the globe from diverse fields are presented in a thematic volume.

The chapters highlight current information scientists have unraveled about the origin, pathogenesis and prevention of AD. The contributions consider both established and emerging drug targets viz. Tau proteins, TREM, and microglia. Topics covered in the book include multi-target anti-Alzheimer's agents, epigenetic modifications, and the role of specific proteins like TMP21 and Tau in AD. A section dedicated to pharmacological treatments discusses the significance of tubulin-modifying enzymes, memantine, and glutamate antagonists. Enzymatic targets for drug discovery are thoroughly examined, focusing on cholinesterase, secretases, and other enzymes. Additionally, the book explores innovative nano-carrier-based drug delivery methods, emphasizing the crucial role of nanotechnology in effective Alzheimer's treatment.

The book aims to inform students and researchers in the field of neuroscience, medicine and pharmacology about current research and biochemical nuances of AD pathogenesis and enzymatic drug targeting strategies.

Readership

Students and researchers in the field of neuroscience, medicine and pharmacology.

Foreword

- Pp. i
Sushil K. Singh
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Preface

- Pp. ii-v (4)
Dileep Kumar, Prashant Tiwari
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List of Contributors

- Pp. vi-viii (3)

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Recent Advances In Tacrine-Based Anti-Alzheimer’s Drug Design

- Pp. 1-26 (26)
Atukuri Dorababu*

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Epigenetics of Alzheimer’s Disease: Past, Present and Future

- Pp. 27-72 (46)
Divya Adiga, Sangavi Eswaran, S. Sriharikrishnaa, Nadeem G. Khan, Shama Prasada Kabekkodu*, Dileep Kumar

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TMP21 in Alzheimer’s Disease: An Important Target For Effective Treatment Approach

- Pp. 73-92 (20)
Dipanjan Karati, Dileep Kumar*

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Tubulin Modifying Enzymes as Target for the Treatment of Alzheimer's Disease: Old Perspective With A New Angle

- Pp. 93-110 (18)
Shweta Shrivastava*, Ayush Kumar, Manish Kumar Jeengar, Chandraprabha Sahu

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Memantine and Glutamate Antagonists in the Treatment of Alzheimer's Disease: Current Updates

- Pp. 111-120 (10)
Rakesh Kore, Priya Tiwari, Vijay K Patel, Ekta Shirbhate, Ravichandran Veerasamy, Achal Mishra, Harish Rajak*

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Enzymatic Targets for Drug Discovery Against Alzheimer's Disease

- Pp. 121-158 (38)
Ahmet Ozan Ozgen, Ozan Emre Eyupoglu*

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Tau Protein: Targets And Development Against Alzheimer’s Disease

- Pp. 159-180 (22)
Sonal Dubey*, Mahesh AR

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Promising Nano-Carriers-Based Targeted Drug Delivery Approaches for the Effective Treatment of Alzheimer’s Disease

- Pp. 181-204 (24)
Yogita Kumari, Khushboo Raj, Pankaj Kumar Singh*

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Effects of Carbonic Anhydrase Inhibitors on Mitochondrial Dysfunction and Consequently on Alzheimer’s Disease

- Pp. 205-220 (16)
Devyani Bhatnagar, Shreya Ladhe, Dileep Kumar*

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Novel Treatment for Alzheimer’s Disease: Tapping the Somatostatin-evoked Aβ Catabolism via α-endosulfine-KATP Channel Pathway

- Pp. 221-243 (23)
Ryan Varghese, Gargi Digholkar, Abha Deshpande, Dileep Kumar*

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Diagnosis and Potential Strategies to Discover New Drugs for the Treatment of Alzheimer’s Disease (AD)

- Pp. 244-265 (22)
Kavya Manjunath*, Arvinder Kaur, Deepa Bagur Parmesh, Shilpa Murthy

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Subject Index

- Pp. 266-271 (6)
Dileep Kumar, Prashant Tiwari
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