Editor: Balkrishna Acharya

Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer

eBook: US $59 Special Offer (PDF + Printed Copy): US $94
Printed Copy: US $65
Library License: US $236
ISBN: 978-981-5079-79-1 (Print)
ISBN: 978-981-5079-78-4 (Online)
Year of Publication: 2023
DOI: 10.2174/97898150797841230101


Triple negative breast cancers (TNBC) are a biologically aggressive form of breast cancer and constitute approximately 10-15% of all breast cancer patients. Distant metastasis, lack of clinically targeted therapies and prognostic markers, makes the disease difficult to treat. Till now not much work has been carried out on this deadly disease.

This book provides an overview of TNBC etiology, its treatment strategies and prognostic markers to identify the outcome of standard therapies. Signalling pathways namely cell proliferation, angiogenesis, invasion and metastasis, apoptosis, autophagy and others involved in complicating the disease have been described in the chapters to convey an understanding about the disease mechanisms. All the possible drugs either in pre-clinical or clinical stages have also been mentioned with data that depicts their efficiency in targeting altered genes. The book also introduces the reader to herbal medicine exhibiting high potency to target TNBC, their synthetic analogs used during chemotherapy and their ability to fight against chemoresistance. The concept of phytonanotechnology has also been discussed. The book helps create awareness among a broad range of readers about TNBC. It points to prioritizing the upgradation of health care facilities and re-designing future treatment strategies to provide maximum benefit to breast cancer patients.


A wide spectrum of readers especially those working in the field of breast cancer medicine, herbal medicine, traditional medicine and basic medical research.


- Pp. i
Swami Ramdev
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- Pp. ii
Acharya Balkrishna
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List of Contributors

- Pp. iii

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Etiological Insights into TNBC and their Related Catastrophic Risks

- Pp. 1-25 (25)
Haritha H Nair, Ruby John Anto*
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A Clinical Cognizance of Molecular and Pathological Diagnostic Approach of TNBC

- Pp. 26-46 (21)
Acharya Balkrishna, Usman Umar Zango, Saima Kauser Nasir, Vedpriya Arya*
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Molecular Sub-Typing and Exploration of Key Signalling Pathways Involved in Complicating the Disease

- Pp. 47-72 (26)
Nikhil Ponnoor Anto, Amitha Muraleedharan, Rashmi Mittal*
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Pre-Clinical and Clinical Evidence of Recent Therapeutic Trends and Spotting Possibility of Cure in Near Future

- Pp. 73-98 (26)
Amitha Muraleedharan, Sagar Kumar, Rashmi Mittal*
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Evaluating Fate of Emerging Resistance Hitting the Brakes on Conventional Treatment Approach

- Pp. 99-122 (24)
Nikhil Ponnoor Anto, Rashmi Mittal*
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Herbal Medicine: Prejudice to Realm of Reality Against TNBC

- Pp. 123-144 (22)
Balachandran S. Vinod, Ruby John Anto*
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Unveiling the Potency of Phyto-Constituents to Target TNBC: Mechanism to Therapeutics

- Pp. 145-160 (16)
Sreekumar Usha Devi Aiswarya, Smitha V. Bava*
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Phyto-nanotechnology: Enhancing Plant Based Chemical Constituent Mediated Anticancer Therapies

- Pp. 161-181 (21)
Usman Umar Zango, Aminu Abubakar, Rohit Saxena, Vedpriya Arya*
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Novel Implications of Prognostic Markers to Monitor the Disease: An Overview

- Pp. 182-197 (16)
Rohit Saxena, Ankit Gupta, Vikrant Singh, Sagar Kumar, Rashmi Mittal*
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Stumbling Blocks in Reinvigorating the Health of Diseased Individuals Through Herbal Medicine

- Pp. 198-207 (10)
Acharya Balkrishna, Rashmi Mittal, Vedpriya Arya*
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Subject Index

- Pp. 208-215 (8)
Acharya Balkrishna
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