Editor: Simone Carradori

Series Title: Medicinal Chemistry Lessons From Nature

Flavonoids and Phenolics

Volume 1

eBook: US $99 Special Offer (PDF + Printed Copy): US $194
Printed Copy: US $144
Library License: US $396
ISBN: 978-981-5079-10-4 (Print)
ISBN: 978-981-5079-09-8 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150790981220101

Introduction

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Each chapter follows a specific format for a phytochemical agent with common chemical features:

- General background on the (phyto)chemistry of the scaffold

- General background on the pharmacological profile of the scaffold

- A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships)

- In silico analysis of the crucial interactions with the biological target

- Clinical studies and patent survey (if available) on the new and proposed structures

The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

Audience

Academic and professional researchers and clinicians in the field of medicinel chemistry and pharmaceutical chemistry.

Foreword

The intention of this volume is to give an overview of the latest discoveries in the research on natural products-derived compounds, through a medicinal chemistry approach of the most exciting topics on flavonoids and (poly)phenolics derivatives. It is structured with innovative book setting outlines and a clear distinction between experimental and clinical results, in order to aid the reader to know at which step of the pipeline each compound is. Due to the scarcity of information of the other competing books, the Guest Editor wants to fulfil the gap of the acquired knowledge in the last few years with the aim to provide a guide for academic and professional researchers and clinicians.

The exploration of the chemical space ranges from flavonoids to phenolic compounds, covering all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies and technological formulations). Each chapter reviews on agents with common chemical features, considering them as scaffolds to obtain various derivatives aiming at the biological activity. The chemical modifications of these agents could increase their intrinsic properties, overcome limitations as drug candidates and introduce new properties. Thus, the volume is intended to be useful to researchers for more concrete applications in the natural product field. As far as I know, this is the first time these data are organized focusing on the synthetic methods and their strategies comprehending the last years.

KEY FEATURES

  1. Updated information on synthetic/natural compounds;
  2. In-depth analysis of novel findings and promising translational applications;
  3. Use of organic reactions as a powerful tool in drug discovery to improve the biological activity or give new chemical and biological properties to the parent molecules;
  4. Molecular mechanisms with innovative approaches for the readers to improve their own research investigations.
Rosa Amoroso
Department of Pharmacy
G. d’Annunzio University of Chieti-Pescara
Via dei Vestini 31, 66100 Chieti (Italy)