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Flavonoids and Phenolics
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Editor: Simone Carradori

Series Title: Medicinal Chemistry Lessons From Nature

Flavonoids and Phenolics

Volume 1
eBook: US $99 Special Offer (PDF + Printed Copy): US $180
Printed Copy: US $131
Library License: US $396
ISBN: 978-981-5079-10-4 (Print)
ISBN: 978-981-5079-09-8 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150790981220101
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Introduction

Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Each chapter follows a specific format for a phytochemical agent with common chemical features:

- General background on the (phyto)chemistry of the scaffold

- General background on the pharmacological profile of the scaffold

- A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships)

- In silico analysis of the crucial interactions with the biological target

- Clinical studies and patent survey (if available) on the new and proposed structures

The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.

Audience

Academic and professional researchers and clinicians in the field of medicinel chemistry and pharmaceutical chemistry.


eBook: US $99 Special Offer: US $180 Printed Copy: US $131 Library License: US $396

Contributors

Editor(s):
Simone Carradori
Department of Pharmacy, G. d’Annunzio
University of Chieti-Pescara
Italy



Contributor(s):
Alessandra Ammazzalorso
Department of Pharmacy, Medicinal Chemistry Unit
G. d’Annunzio University of Chieti-Pescara
Via dei Vestini, 66100 Chieti
Italy


Alessandro Bonardi
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences
Pharmaceutical and Nutraceutical Section, University of Florence, Via U
Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Alessio Nocentini
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences
Pharmaceutical and Nutraceutical Section, University of Florence, Via U
Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Antonella Capperucci
Department of Chemistry “Ugo Schiff”
University of Florence
Via della Lastruccia 13, I-50019 Sesto Fiorentino
Italy


Arafa Musa
Department of Pharmacognosy
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Atilla Akdemir
Computer-aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy
Bezmialem Vakif University
Fatih, Istanbul 34093
Turkey


Barbara De Filippis
Department of Pharmacy
“G. d’Annunzio” University of Chieti-Pescara
Via dei Vestini 31, 66100 Chieti
Italy


Bijo Mathew
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India


Celeste De Monte
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Claudio Ferrante
Department of Pharmacy, Medicinal Plant Unit (MPU), Botanic Garden Giardino dei Semplici
G. d’Annunzio University of Chieti-Pescara
Via dei Vestini, 66100 Chieti
Italy


Claudiu T. Supuran
Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, Pharmaceutical and Nutraceutical Section
University of Florence
Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze
Italy


Cristina Scarpecci
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Damiano Tanini
Department of Chemistry “Ugo Schiff”
University of Florence
Via della Lastruccia 13, I-50019 Sesto Fiorentino
Italy


Della Grace Thomas Parambi
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Federico Appetecchia
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Federico De Paolis
Department of Physiology and Pharmacology “V. Ersparmer”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome
Italy


Francesco Cairone
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Giovanna Poce
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Heiko Lange
Department of Environmental and Earth Sciences
University of Milano-Bicocca
Milan
Italy


Leena K Pappachen
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India


Luc Zongo
Department of Pharmacy
University of Saint Dominic of West Africa (USDAO)
Doulougou
Burkina Faso


Mohamed A. Abdelgawad
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Manoj Kumar Sachidanandan
Department of Oral and maxillofacial surgery and diagnostics
College of Dentistry, Hail University
Hail Province, 2440
Saudi Arabia


Maria Antonietta Casadei
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Melissa D’Ascenzio
D’Arcy Thompson Unit, Biological and Biomedical Sciences Education
School of Life Sciences, University of Dundee
DD1 4HN, Dundee
UK


Mutairah Shaker Alshammari
Department of Pharmaceutical Analytical Chemistry, Faculty of science
Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Paolo Guglielmi
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Rania Bakr
Department of Pharmaceutical Chemistry
College of Pharmacy, Jouf University
Sakaka, Al Jouf, 2014
Saudi Arabia


Sara Consalvi
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Stefania Cesa
Department of Drug Chemistry and Technology
Sapienza, University of Rome
00185 Rome
Italy


Stefania Garzoli
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Stefania Petralito
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Trond Vidar Hansen
Department of Pharmacy
Section for Pharmaceutical Chemistry, University of Oslo
PO Box 1068 Blindern, N-0316 Oslo
Norway


Virginia Pontecorvi
Department of Drug Chemistry and Technologies
Sapienza University of Rome
P.le A. Moro 5, 00185 Rome
Italy


Vaishnav Bhaskar
Department of Pharmaceutical Chemistry
Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus
Kochi-682 041
India