Editor: Simone Carradori

Series Title: Medicinal Chemistry Lessons From Nature

Flavonoids and Phenolics

Volume 1

eBook: US $99 Special Offer (PDF + Printed Copy): US $180
Printed Copy: US $131
Library License: US $396
ISBN: 978-981-5079-10-4 (Print)
ISBN: 978-981-5079-09-8 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150790981220101


Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.

This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.

Each chapter follows a specific format for a phytochemical agent with common chemical features:

- General background on the (phyto)chemistry of the scaffold

- General background on the pharmacological profile of the scaffold

- A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships)

- In silico analysis of the crucial interactions with the biological target

- Clinical studies and patent survey (if available) on the new and proposed structures

The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.


Academic and professional researchers and clinicians in the field of medicinel chemistry and pharmaceutical chemistry.


- Pp. i
Rosa Amoroso
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- Pp. ii
Simone Carradori
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List of Contributors

- Pp. iii-iv (2)

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Polyphenols and Flavonoids: Chemical, Pharmacological and Therapeutic Aspects

- Pp. 1-26 (26)
Stefania Cesa*, Francesco Cairone, Celeste De Monte
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Recent Development of Hybrids and Derivatives of Resveratrol in Neurodegenerative Diseases

- Pp. 27-72 (46)
Barbara De Filippis*, Marialuigia Fantacuzzi
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Biological Activities of Synthetic Derivatives of Xanthones: An Update (2016-2020)

- Pp. 73-111 (39)
Cristina Scarpecci, Sara Consalvi*
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Combretastatin Derivatives as Tubulin Inhibitors: A Fascinating Journey from Nature to Drug Discovery Strategies

- Pp. 112-144 (33)
Alessandra Ammazzalorso*, Trond Vidar Hansen
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Natural Flavonoid and Chalcone Scaffolds as Leads for Synthetic Antitubercular Agents

- Pp. 145-172 (28)
Federico Appetecchia, Mariangela Biava, Giovanna Poce*
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In Silico Approaches to Naturally Existing Chalcones and Flavonoids on Mao Inhibitory Action: A Boon to CNS Drug Discovery

- Pp. 173-195 (23)
Arafa Musa, Manoj Kumar Sachidanandan, Della Grace Thomas Parambi, Mutairah Shaker Alshammari, Rania Bakr, Mohammed A. Abdelgawad, Dibya Sundar Panda, Vaishnav Bhaskar, Leena K. Pappachen, Bijo Mathew
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Lignins and Lignans – Recent Developments and Trends Regarding their Pharmaceutical Properties

- Pp. 196-248 (53)
Luc Zongo, Heiko Lange*
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Semisynthetic Resveratrol-derived Systems: A Synergism between Nature and Organic Synthesis

- Pp. 249-271 (23)
Antonella Capperucci, Damiano Tanini*
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Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors

- Pp. 272-297 (26)
Paolo Guglielmi, Virginia Pontecorvi*, Atilla Akdemir
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Coumarins as Carbonic Anhydrase Inhibitors

- Pp. 298-329 (32)
Claudiu T. Supuran*
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Phenols and Polyphenols as Carbonic Anhydrase Inhibitors

- Pp. 330-383 (54)
Alessandro Bonardi, Claudiu T. Supuran, Alessio Nocentini*
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The Role of Flavonoids and other Selected (Poly) Phenols in Cancer Prevention and Therapy: A Focus on Epigenetics

- Pp. 384-489 (106)
Melissa D’Ascenzio*
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Subject Index

- Pp. 490-506 (17)
Simone Carradori
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