Editors: Rupesh K. Gautam, Lokesh Deb, Kamal Dua

Series Title: Frontiers in Arthritis

Natural Products for the Management of Arthritic Disorders

Volume 5

eBook: US $69 Special Offer (PDF + Printed Copy): US $117
Printed Copy: US $83
Library License: US $276
ISSN: 2468-6662 (Print)
ISSN: 2468-6670 (Online)
ISBN: 978-981-5050-78-3 (Print)
ISBN: 978-981-5050-77-6 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150507761220101


Rheumatoid arthritis (RA) is the most common inflammatory complication and affects approximately 1 % of the global population. It affects three times more women than men. RA is an autoimmune disorder elicited by exposure of genetic factors from the host to unknown antigens causing arthritogenic complaints. It also includes the activation of lymphocytes as well as CD4+ helper T cells along with the local release of chronic inflammatory mediators and cytokines like tumor necrosis factor (TNF‐α) and various cytokines like interleukins (IL) that enormously affect the joints. The available allopathic therapies for RA are not a cure for the complications, and antibody therapy and surgical procedures are expensive.

However, in the present era, researchers and healthcare professionals have moved toward natural medicines obtained from plants and other natural sources. Research-based on developments in phytomedicine has progressed steadily. Evidence has been collected to show the massive therapeutic potential of medicinal plants used in various traditional systems against many pathological complications. Researchers have focused on the therapeutic potential of natural products used for treatment and counteracting various disorders along with their complications having negligible adverse effects.

Natural Products for the Management of Arthritic Disorders compiles current knowledge about the bioactive compounds and herbal formulations useful in the treatment of rheumatoid arthritis. 11 chapters explain the role of natural products in the management of rheumatoid arthritis. Topics have been contributed by experts in medicinal chemistry and rheumatology.

The book first introduces the reader to rheumatoid arthritis before delving into conventional and alternative therapies for the disease. The editors have also included special topics such as the biomarkers for RA, cytokines and anti-inflammatory mediators, and preclinical and clinical studies. The range of topics should provide a comprehensive overview of natural remedies for arthritis and the role of natural products in anti-arthritic drug development.

The information will be useful for many readers including medical and pharmacology students, multidisciplinary research scholars, scientists, pharma/herbal/food industrialists, and policymakers.

Audience: Medical and pharmacology students, multidisciplinary research scholars, scientists, pharma/herbal/food industrialists, and policymakers.


- Pp. i
Rupesh K. Gautam, Lokesh Deb, Kamal Dua
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List of Contributors

- Pp. ii-iii (2)

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Rheumatoid Arthritis: Introduction

- Pp. 1-25 (25)
Diptendu Bhowmik, Venu Kola, Subba Rao Chamakuri, Chiranjib Bhattacharjee*
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Conventional Therapy for Rheumatoid Arthritis

- Pp. 26-49 (24)
Anil T. Pawar, Akshay M. Baheti*, Pallavi Adate-More, Aman Upaganlawar
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Role of Biomarkers in Rheumatoid Arthritis

- Pp. 50-71 (22)
Hitesh Malhotra*, Anjoo Kamboj
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Bioactive Compounds in Rheumatoid Arthritis

- Pp. 72-96 (25)
Sudha Vengurlekar*, Subhash Chandra Chaturvedi
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Traditional Medicinal Plants: Safe and Efficacious Potential Drugs in the Management of Rheumatoid Arthritis

- Pp. 97-117 (21)
Sarath Nalla*, Sahdeo Prasad, Lakshmi Kavuri, Vijetha Pendyala
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Inflammatory Mediators and Cytokines involved in Rheumatoid Arthritis

- Pp. 118-134 (17)
Vikash Sharma, Shiv Shankar Shukla, Amber Vyas, Ravindra Kumar Pandey
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Natural Products Targeting Various Mediators in Rheumatoid Arthritis

- Pp. 135-163 (29)
Disha Arora, Sanjay Sharma, Sumeet Gupta
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Herbal Formulations Useful in the Treatment of Rheumatoid Arthritis

- Pp. 164-192 (29)
Akshay M. Baheti, Anil T. Pawar
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Preclinical and Clinical Studies on Natural Products Used in Rheumatoid Arthritis

- Pp. 193-217 (25)
Anil Kamboj, Randhir Singh
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Phytochemicals: A New Approach for Targeting Biomarkers in the Management of Arthritis

- Pp. 218-242 (25)
Hitesh Malhotra, Anjoo Kamboj, Peeyush Kaushik
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Potential Biomolecules from the Natural Sources for the Treatment of Rheumatoid Arthritis: A Detailed Review

- Pp. 243-262 (20)
Ajeya Samanta, Dhruba Bhattacharya, Kamalika Mazumder, Shreyans Kumar Jain, Kaushik Biswas*
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Subject Index

- Pp. 263-276 (14)

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