Editors: Rupesh K. Gautam, Lokesh Deb, Kamal Dua

Series Title: Frontiers in Arthritis

Natural Products for the Management of Arthritic Disorders

Volume 5

eBook: US $69 Special Offer (PDF + Printed Copy): US $126
Printed Copy: US $91
Library License: US $276
ISSN: 2468-6662 (Print)
ISSN: 2468-6670 (Online)
ISBN: 978-981-5050-78-3 (Print)
ISBN: 978-981-5050-77-6 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150507761220101

Introduction

Rheumatoid arthritis (RA) is the most common inflammatory complication and affects approximately 1 % of the global population. It affects three times more women than men. RA is an autoimmune disorder elicited by exposure of genetic factors from the host to unknown antigens causing arthritogenic complaints. It also includes the activation of lymphocytes as well as CD4+ helper T cells along with the local release of chronic inflammatory mediators and cytokines like tumor necrosis factor (TNF‐α) and various cytokines like interleukins (IL) that enormously affect the joints. The available allopathic therapies for RA are not a cure for the complications, and antibody therapy and surgical procedures are expensive.

However, in the present era, researchers and healthcare professionals have moved toward natural medicines obtained from plants and other natural sources. Research-based on developments in phytomedicine has progressed steadily. Evidence has been collected to show the massive therapeutic potential of medicinal plants used in various traditional systems against many pathological complications. Researchers have focused on the therapeutic potential of natural products used for treatment and counteracting various disorders along with their complications having negligible adverse effects.

Natural Products for the Management of Arthritic Disorders compiles current knowledge about the bioactive compounds and herbal formulations useful in the treatment of rheumatoid arthritis. 11 chapters explain the role of natural products in the management of rheumatoid arthritis. Topics have been contributed by experts in medicinal chemistry and rheumatology.

The book first introduces the reader to rheumatoid arthritis before delving into conventional and alternative therapies for the disease. The editors have also included special topics such as the biomarkers for RA, cytokines and anti-inflammatory mediators, and preclinical and clinical studies. The range of topics should provide a comprehensive overview of natural remedies for arthritis and the role of natural products in anti-arthritic drug development.

The information will be useful for many readers including medical and pharmacology students, multidisciplinary research scholars, scientists, pharma/herbal/food industrialists, and policymakers.

Audience: Medical and pharmacology students, multidisciplinary research scholars, scientists, pharma/herbal/food industrialists, and policymakers.

Preface

Rheumatoid arthritis (RA) is the most common inflammatory complication that affects about 1 % of the population. It affects three times more women than men. RA is an autoimmune disorder elicited by exposure of genetic factors from the host to unknown antigens causing arthritogenic complaints. It also includes the activation of lymphocytes as well as CD4+ helper T cells along with local release of chronic inflammatory mediators and cytokines like tumor necrosis factor (TNF-α) and various cytokines like interleukins (IL) that enormously affect the joints. The available allopathic therapies for RA are not worthwhile to cure the complication and antibody therapy and surgical procedure are very expensive that cannot be afforded by middle class people.

However, in the present era, researchers and healthcare professionals have moved toward natural medicine obtained from plants and other natural sources. The research, based on development of phytomedicine, has globally increased. Evidence has been collected to show the massive therapeutic potential of medicinal plants used in various traditional systems against many pathological complications. In the present scenario, researchers have focused on the therapeutic potential of natural products used for treatment and counteracting various disorders along with their complications having negligible adverse effects. The main objective of this book is to collect the knowledge about the bioactive compounds/herbal formulations useful in the treatment of rheumatoid arthritis.

This book entitled ‘Natural Products for the Management of Arthritic Disorders’ contents the chapter related with role of various natural products, herbal formulations etc. in the treatment of RA. It covers various cytokines/mediators and biomarkers involved in RA. Clinical studies are also included.

We are very thankful and grateful to all the contributors who helped us to develop this fruitful book with a comprehensive literature review and compiled research work. All valuable facts are collected and brought together to form a good knowledgeable literature. We hope that this work will help to contribute a good content for future projects based on natural products in RA.

We extend our thanks to the Bentham Science Publishers for giving this opportunity.

Rupesh K. Gautam
Department of Pharmacology
MM School of Pharmacy
Maharishi Markandeshwar University
Ambala-Chandigarh Highway
Sadopur- Ambala-134007 (Haryana), India

Lokesh Deb
Institute of Bioresources and Sustainable
Development (IBSD) – Regional Centre Sikkim,
Department of Biotechnology,
Ministry of Science & Technology
Government of India
Tadong, Gangtok -737102
East Sikkim, Sikkim
India

&

Kamal Dua
Discipline of Pharmacy
Graduate School of Health
Faculty of Health
Australian Research Centre in
Complementary and Integrative Medicine (ARCCIM)
University of Technology Sydney
Sydney, Australia