Editor: Asis Bala

Free Radical Biology of Endocrine, Metabolic & Immune Disorders

eBook: US $49 Special Offer (PDF + Printed Copy): US $90
Printed Copy: US $65
Library License: US $196
ISBN: 978-981-5049-23-7 (Print)
ISBN: 978-981-5049-22-0 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150492201220101

Introduction

This reference explores the science of signaling mechanisms associated with diseases like endocrine, metabolic, and immune disorders which are linked to oxidative stress-mediated disease mechanisms. The common diseases in these categories include diabetes mellitus and arthritis and conditions defined by inflammation and autoimmunity. These diseases involve metabolic pathways mediated by reactive oxygen species or free radicals. The pathways are targets in the mechanism of drugs that aim to treat related disorders. The book covers key topics in free radical biology that help to understand the nature of the pathways and the pharmacology of the drugs that are designed to target them.

5 chapters elucidate the free radical biology of the diseases.

1. Role of free radical biology in diabetes mellitus

2. Role of GSK3 in the regulation of insulin release and glucose metabolism

3. Regulatory role of NRF2 in rheumatoid arthritis

4. Role of free radical biology in Alzheimer’s disease

5. Regulatory role of immune cells mediated antibody on rheumatoid arthritis

Key features:

- Elucidates the key biochemical and pharmacological mechanisms that are mediated by free radicals in common endocrine, metabolic and immune diseases

- Explains the activation of immunological factors (like RF and ACPA) that trigger inflammation and arthritis

- Covers the role of free radicals in Alzheimer’s disease and new interventions that target mitochondrial mechanisms

- Systematically explains the molecular biology of free radicals with the help of schematic diagrams

- Includes references for further reading

The accessible and structured text in this reference makes it a suitable resource for all biomedical scientists, faculty, and postgraduate students in academia and industry.

Audience: Academic faculty, postgraduate researchers in pharmaceutical science, pharmacy, pharmacology, biochemistry, molecular biology

Contributors

Editor(s):
Asis Bala
Division of Pharmacology and Toxicology
Guru Nanak Institute of Pharmaceutical Science of Technology (Autonomous Pharmacy Institute)
Kolkata 700114, West Bengal
India




Contributor(s):
Ashok Kumar Balaraman
UCSI University; UCSI Heights, 1
Jalan Puncak Menara Gading, Taman Connaught
56000 Cheras, Wilayah Persekutuan Kuala Lumpur
Malaysia


Asis Bala
Division of Pharmacology and Toxicology
Guru Nanak Institute of Pharmaceutical Science and Technology
157/F, Nilgunj Road
Panihati, Sodepur
Kolkata-700114
India


Barsha Dassarma
Department of Pharmacology
School of Medicine, Faculty of Health Sciences
University of the Free State, Bloemfontein, 9300
South Africa


Bidita Khandelwal
Department of Medicine
Sikkim Manipal Institute of Medical Sciences
Sikkim Manipal University
Gangtok, Sikkim-737102
India


Chamma Gupta
Department of Biochemistry
Sikkim Manipal Institute of Medical Sciences
Sikkim Manipal University
Gangtok, Sikkim-737102
India


Chaitali Mondal
TCG Life Sciences (Chembiotek) Pvt. Ltd
Sector V, Salt Lake Electronics Complex
Kolkata, West Bengal 700091
India


Debjeet Sur
Division of Pharmacology and Toxicology
Guru Nanak Institute of Pharmaceutical Science and Technology
157/F, Nilgunj Road
Panihati, Sodepur
Kolkata-700114
India


Debanjana Das
Department of Biotechnology
National Institute of Pharmaceutical Education and Research
EPIP Campus
Hajipur, Bihar 844102
India


Himangshu Sekhar Maji
Department of Pharmaceutical Technology
JIS University, 81, Nilgunj Rd
Jagarata Pally, Deshpriya Nagar
Agarpara, Kolkata
West Bengal 700109
India


Karma Gurmey Dolma
Department of Microbiology
Sikkim Manipal Institute of Medical Sciences
Sikkim Manipal University
Gangtok, Sikkim-737102
India


Levin Thomas
Department of Pharmacy Practice
Manipal College of Pharmaceutical Sciences
Manipal Academy of Higher Education
Manipal, Karnataka-576104
India


Lopamudra Roy
School of Pharmaceutical Sciences
Apeejay Stya University, Sohna - Palwal Road
Sohna – 122103
Gurugram, Haryana
India


Mahadev Rao
Department of Pharmacy Practice
Manipal College of Pharmaceutical Sciences
Manipal Academy of Higher Education
Manipal, Karnataka-576104
India


Motlalepula Gilbert Matsabisa
Department of Pharmacology
School of Medicine, Faculty of Health Sciences
University of the Free State
Bloemfontein, 9300
South Africa


Mohammed Alsaweed
Department of Medical Laboratory Sciences
College of Applied Medical Sciences
Majmaah University
Majmaah 11952
Saudi Arabia


Nileswar Das
Department of Psychiatry and NDDTC
All India Institute of Medical Sciences
New Delhi
India


Pallab Kanti Haldar
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 188 Raja SC Mullick Road, 700032
India


Rubi Dey
Department of Physiology
Sikkim Manipal Institute of Medical Sciences
Sikkim Manipal University
Gangtok, Sikkim-737102
India


Rinchen Doma Bhutia
Department of Biochemistry
Sikkim Manipal Institute of Medical Sciences
Sikkim Manipal University
Gangtok, Sikkim-737102
India


Sonal Sekhar Miraj
Department of Pharmacy Practice
Manipal College of Pharmaceutical Sciences
Manipal Academy of Higher Education, Manipal
Karnataka-576104
India


Satyajit Tripathy
Department of Pharmacology
School of Medicine, Faculty of Health Sciences
University of the Free State
Bloemfontein, 9300
South Africa


Samrat Singh Bhandari
Department of Psychiatry
Sikkim Manipal Institute of Medical Sciences
Sikkim Manipal University
Sikkim
India


Sumit Kumar
Department of Chemistry
B.S.S College, Supaul
B.N. Mandal University
Madhepura, Bihar 852131
India


Vijay Pratap Singh
Department of Physiotherapy
Kasturba Medical College
Manipal Academy of Higher Education
Mangalore, Karnataka-575001
India


Vatsala Sharma
Mount Sinai Services of the Icahn School of Medicine
Mount Sinai-Elmhurst Hospital Center, Psychiatry
79-01 Broadway, Queens, NY 11373
United States