Editor: Asis Bala

Free Radical Biology of Endocrine, Metabolic & Immune Disorders

eBook: US $49 Special Offer (PDF + Printed Copy): US $83
Printed Copy: US $59
Library License: US $196
ISBN: 978-981-5049-23-7 (Print)
ISBN: 978-981-5049-22-0 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150492201220101


This reference explores the science of signaling mechanisms associated with diseases like endocrine, metabolic, and immune disorders which are linked to oxidative stress-mediated disease mechanisms. The common diseases in these categories include diabetes mellitus and arthritis and conditions defined by inflammation and autoimmunity. These diseases involve metabolic pathways mediated by reactive oxygen species or free radicals. The pathways are targets in the mechanism of drugs that aim to treat related disorders. The book covers key topics in free radical biology that help to understand the nature of the pathways and the pharmacology of the drugs that are designed to target them.

5 chapters elucidate the free radical biology of the diseases.

1. Role of free radical biology in diabetes mellitus

2. Role of GSK3 in the regulation of insulin release and glucose metabolism

3. Regulatory role of NRF2 in rheumatoid arthritis

4. Role of free radical biology in Alzheimer’s disease

5. Regulatory role of immune cells mediated antibody on rheumatoid arthritis

Key features:

- Elucidates the key biochemical and pharmacological mechanisms that are mediated by free radicals in common endocrine, metabolic and immune diseases

- Explains the activation of immunological factors (like RF and ACPA) that trigger inflammation and arthritis

- Covers the role of free radicals in Alzheimer’s disease and new interventions that target mitochondrial mechanisms

- Systematically explains the molecular biology of free radicals with the help of schematic diagrams

- Includes references for further reading

The accessible and structured text in this reference makes it a suitable resource for all biomedical scientists, faculty, and postgraduate students in academia and industry.

Audience: Academic faculty, postgraduate researchers in pharmaceutical science, pharmacy, pharmacology, biochemistry, molecular biology


Free radicals and other mediated oxidants, especially superoxide (O2-) and hydrogen peroxide (H2O2), have attained great importance in the field of biology due to the pivotal role in a wide range of physiological conditions as well as their implication in endocrine, metabolic and immune diseases [1-3]. The regulatory role of different cellular signalling mechanisms, especially GSK-3, Nrf2, NF-κB mediated oxidative response for different disease progression and aetiology, is still not well understood [4-7]. The proposed book entitled "Free Radical Biology of Endocrine, Metabolic & Immune disorders" aims to enumerate the scientific exploration of the signalling mechanism associated with the targeted disease and the proposed mechanism of drugs target for management with a number of schematic representations so that the biomedical scientist may be facilitated.

As the goal of basic biomedical research is to provide a comprehensive and in-depth understanding of the disease mechanisms underlying the development and normal function of living organisms, the proposed book will hopefully reach all biomedical scientists worldwide, especially those who are looking for better ways to discover drugs in the field of endocrine, metabolic and immune disorders targeting the oxidative stress-mediated disease mechanism.

Asis Bala, Ph.D

Division of Pharmacology and Toxicology,
Guru Nanak Institute of Pharmaceutical Science of Technology
(Autonomous Pharmacy Institute) Kolkata 700114, West Bengal, India