Editor: José Juan Antonio Ibarra Arias

Frontiers in Clinical Drug Research – Dementia

Volume 2

eBook: US $69 Special Offer (PDF + Printed Copy): US $124
Printed Copy: US $90
Library License: US $276
ISSN: 2717-5987 (Print)
ISSN: 2717-5995 (Online)
ISBN: 978-981-5039-48-1 (Print)
ISBN: 978-981-5039-47-4 (Online)
Year of Publication: 2021
DOI: 10.2174/97898150394741210201

Introduction

Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease the prevalence of which is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and therapeutic strategies in order to understand and mitigate this debilitating pathology.

This volume of Frontiers in Clinical Drug Research - Dementia explores the current comorbidities that cause cognitive impairment and the current management alternatives for clinical cases of dementia. The reviews contributed in these volume will provide readers with a current perspective on the subject. The topics covered in this volume include:

  • - Comorbidities inducing mild cognitive impairment - an evaluation of the risk caused by some pathological conditions
  • - Tau-targeted therapy in Alzheimer's disease - history and current state
  • - Emerging nanotherapeutic strategies in Alzheimer's disease
  • - Implication of dehydroepiandrosterone on dementia related to oxidative stress
  • - Polyphenol compounds as potential therapeutic agents in Alzheimer’s disease

The volume is a timely update on dementia treatment for clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.

Audience: clinical physicians, neurologists, gerontologists, pharmaceutical and medicinal chemistry researchers, and physiologists.

Preface

Among neurodegenerative diseases, those that lead to a state of dementia are the aim of several investigations. Dementia is a chronic disease whose prevalence is increasing worldwide. The number of dementia patients in the world is approximately 50 million, and it is estimated that the number of patients will reach 131.5 million by 2050. This increase will be accompanied by a significant increase in medical expenditures and other expenses, especially for elderly patients. Therefore, the maintenance cost of dementia in the future is expected to be quite high. For this reason, several investigations aim, firstly, to describe the key mechanisms involved in the origin of dementia and, secondly, to establish preventive and/or therapeutic strategies in order to understand and mitigate this catastrophic pathology. This book aims to discuss the current comorbidities that cause cognitive impairment and the current management alternatives in cases of dementia for a better understanding of the current perspective on the subject.

The book contains five chapters that begin with a clear description of the comorbidities that induce mild cognitive impairment, continues with the description of some mechanisms that contribute to the development of dementia, and then moves on to the discussion of some encouraging therapies.

The editor would like to express his gratitude to the authors of the chapters presented in this book for their invaluable contributions.

Dr. José Juan Antonio Ibarra Arias
Centro de Investigación en Ciencias de la Salud (CICSA)
Facultad de Ciencias de la Salud Universidad Anáhuac México
University of Cambridge
Norte
Mexico

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